Reactome | CCND1 [nucleoplasm]

CCND1 [nucleoplasm]

Stable Identifier

R-SSC-113832

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

nucleoplasm

Synonyms

CCND1, A0A287BRJ4

Locations in the PathwayBrowser

Expand all

Cell Cycle (Sus scrofa)

- Cell Cycle, Mitotic (Sus scrofa)
  - Mitotic G1 phase and G1/S transition (Sus scrofa)
    - G1 Phase (Sus scrofa)
      - Cyclin D associated events in G1 (Sus scrofa)
        
        CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Sus scrofa)
        
        CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Sus scrofa)
        
        CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CDK4/6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        CDK4:CCND [nucleoplasm] (Sus scrofa)
        
        CDK4:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D1:Cdk6 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND1:CDK6 inhibitors (CCND1) [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        Drug-mediated inhibition of CDK4/CDK6 activity (Sus scrofa)
        
        CDK4 inhibitors bind CDK4 (Sus scrofa)
        
        p-T172-CDK4:CCND [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        CDK6 inhibitors bind CDK6 (Sus scrofa)
        
        p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND1:CDK6 inhibitors (CCND1) [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND [nucleoplasm] (Sus scrofa)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Sus scrofa)
        
        CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Sus scrofa)
        
        CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Sus scrofa)
        
        CDK4/6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        CDK4:CCND [nucleoplasm] (Sus scrofa)
        
        CDK4:CCND1 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        CDK6:CCND [nucleoplasm] (Sus scrofa)
        
        Cyclin D1:Cdk6 [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)
        
        Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Sus scrofa)
        
        Cyclin D [nucleoplasm] (Sus scrofa)
        
        CCND1 [nucleoplasm] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A287BRJ4

Gene Names

CCND1

Reference Genes

ENSEMBL:ENSSSCG00000037900.2

Reference Transcript

RefSeq:XM_013994006.1 CCND1

Other Identifiers

100738589

GO:0000082

GO:0000122

GO:0000278

GO:0000307

GO:0000320

GO:0001934

GO:0003714

GO:0003824

GO:0004672

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005923

GO:0006351

GO:0006355

GO:0006974

GO:0007049

GO:0007595

GO:0008283

GO:0009410

GO:0010971

GO:0012501

GO:0016055

GO:0016301

GO:0016538

GO:0016740

GO:0017053

GO:0019899

GO:0019901

GO:0023052

GO:0030154

GO:0030182

GO:0030857

GO:0030968

GO:0031571

GO:0031965

GO:0033598

GO:0033601

GO:0036211

GO:0042826

GO:0043226

GO:0043524

GO:0044321

GO:0044772

GO:0045444

GO:0048856

GO:0051301

GO:0051726

GO:0060749

GO:0061575

GO:0070064

GO:0070141

GO:0071310

GO:0097128

GO:0097421

GO:0098772

GO:0140096

GO:0140110

GO:2000045

Participates

as a component of

as a candidate of

CCND3,(CCND1,CCND2) [nucleoplasm] (Sus scrofa)

as an input of

CCND1 binds RUNX3 and displaces EP300 (Sus scrofa)

as a member of

Cyclin D [nucleoplasm] (Sus scrofa)

Other forms of this molecule

phospho-CCND1 [cytosol]

phospho-CCND1 [nucleoplasm]

CCND1 [cytosol]

Inferred From

CCND1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_013849460.1

OpenTargets

ENSG00000110092

Ensembl

ENSSSCT00000046016, ENSSSCP00000059262, ENSSSCG00000037900

VGNC

86352

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