Reactome | ucp8 [cytosol]

ucp8 [cytosol]

Stable Identifier

R-SPO-8862264-2

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

cytosol

Synonyms

ITSN2, O94685

Locations in the PathwayBrowser

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Signal Transduction (Schizosaccharomyces pombe)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Schizosaccharomyces pombe)
  - Signaling by Rho GTPases (Schizosaccharomyces pombe)
    - RHO GTPase cycle (Schizosaccharomyces pombe)
      - RHOU GTPase cycle (Schizosaccharomyces pombe)
        
        RHOU binds effectors at the plasma membrane (Schizosaccharomyces pombe)
        
        RHOU effectors [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of ITSN2 [cytosol] (Schizosaccharomyces pombe)
        
        ucp8 [cytosol] (Schizosaccharomyces pombe)
        
        RHOU:GTP:RHOU effectors [plasma membrane] (Schizosaccharomyces pombe)
        
        RHOU effectors [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of ITSN2 [cytosol] (Schizosaccharomyces pombe)
        
        ucp8 [cytosol] (Schizosaccharomyces pombe)

Vesicle-mediated transport (Schizosaccharomyces pombe)

- Membrane Trafficking (Schizosaccharomyces pombe)
  - Clathrin-mediated endocytosis (Schizosaccharomyces pombe)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Schizosaccharomyces pombe)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Schizosaccharomyces pombe)
        
        ITSNs [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of ITSN2 [cytosol] (Schizosaccharomyces pombe)
        
        ucp8 [cytosol] (Schizosaccharomyces pombe)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Schizosaccharomyces pombe)
        
        ITSNs [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of ITSN2 [cytosol] (Schizosaccharomyces pombe)
        
        ucp8 [cytosol] (Schizosaccharomyces pombe)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Schizosaccharomyces pombe)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Schizosaccharomyces pombe)
        
        ITSNs [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of ITSN2 [cytosol] (Schizosaccharomyces pombe)
        
        ucp8 [cytosol] (Schizosaccharomyces pombe)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Schizosaccharomyces pombe)
        
        ITSNs [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of ITSN2 [cytosol] (Schizosaccharomyces pombe)
        
        ucp8 [cytosol] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:O94685

Gene Names

ucp8

Reference Genes

BioGPS Gene:2540786 ucp8

ENSEMBL:SPBC83.01

KEGG Gene (Schizosaccharomyces pombe):SPBC83.01 ucp8

Monarch:2540786 ucp8

NCBI Gene:2540786 ucp8

PomBase:SPBC83.01

Reference Transcript

RefSeq:NM_001021527.2 ucp8

Participates

as a member of

Homologues of ITSN2 [cytosol] (Schizosaccharomyces pombe)

Other forms of this molecule

ucp8 [cytosol]

Inferred From

ITSN2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_595633.2

PRO

O94685