Reactome | rpl301 [cytosol]

rpl301 [cytosol]

Stable Identifier

R-SPO-72450-2

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

cytosol

Synonyms

RPL3L, P40372

Locations in the PathwayBrowser

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Metabolism of RNA (Schizosaccharomyces pombe)

- Nonsense-Mediated Decay (NMD) (Schizosaccharomyces pombe)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
    - SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Schizosaccharomyces pombe)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)

Metabolism of proteins (Schizosaccharomyces pombe)

- Translation (Schizosaccharomyces pombe)
  - Eukaryotic Translation Initiation (Schizosaccharomyces pombe)
    - Cap-dependent Translation Initiation (Schizosaccharomyces pombe)
      - Formation of a pool of free 40S subunits (Schizosaccharomyces pombe)
        
        Release of 40S and 60S subunits from the 80S ribosome (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Schizosaccharomyces pombe)
        
        The 60S subunit joins the translation initiation complex (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
        
        eIF5B:GTP is hydrolyzed and released (Schizosaccharomyces pombe)
        
        80S:Met-tRNAi:mRNA [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Schizosaccharomyces pombe)
      - Dissociation of L13a from the 60s ribosomal subunit (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
        
        60s ribosomal complex lacking L13a subunit [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
  - SRP-dependent cotranslational protein targeting to membrane (Schizosaccharomyces pombe)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Schizosaccharomyces pombe)
      - SRP:polypeptide+signal:ribosome [cytosol] (Schizosaccharomyces pombe)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        60S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        RPL3,RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)
        
        rpl301 [cytosol] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:P40372

Gene Names

rpl301

Reference Genes

BioGPS Gene:2542265 rpl301

ENSEMBL:SPAC17A5.03

GeneDB:SPAC17A5.03

KEGG Gene (Schizosaccharomyces pombe):SPAC17A5.03 rpl301

Monarch:2542265 rpl301

NCBI Gene:2542265 rpl301

Reference Transcript

RefSeq:NM_001018904.2 rpl301

Participates

as a member of

Homologues of RPL3L [cytosol] (Schizosaccharomyces pombe)

Other forms of this molecule

rpl301 [cytosol]

Inferred From

RPL3L [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_593471.1

PRO

P40372

PDB

8ESR, 8ESQ, 8EUY, 8EUI, 8ETJ, 8EUG, 8ETI, 8ETH, 8EV3, 8ETG, 8EUP, 8ETC

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