Reactome | rps21 [cytosol]

rps21 [cytosol]

Stable Identifier

R-SPO-72351

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

cytosol

Synonyms

RPS21, P05764

Locations in the PathwayBrowser

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Metabolism of RNA (Schizosaccharomyces pombe)

- Nonsense-Mediated Decay (NMD) (Schizosaccharomyces pombe)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Schizosaccharomyces pombe)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        rps21 [cytosol] (Schizosaccharomyces pombe)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        rps21 [cytosol] (Schizosaccharomyces pombe)
    - SMG6 hydrolyzes mRNA with premature termination codon (Schizosaccharomyces pombe)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        rps21 [cytosol] (Schizosaccharomyces pombe)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Schizosaccharomyces pombe)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Schizosaccharomyces pombe)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        rps21 [cytosol] (Schizosaccharomyces pombe)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Schizosaccharomyces pombe)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Schizosaccharomyces pombe)
        
        80S ribosome [cytosol] (Schizosaccharomyces pombe)
        
        40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)
        
        rps21 [cytosol] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:P05764

Gene Names

rps21

Reference Genes

BioGPS Gene:2540806 rps21

ENSEMBL:SPBC18E5.06

KEGG:spo:SPBC18E5.06 rps21

Monarch:2540806 rps21

NCBI Gene:2540806 rps21

PomBase:SPBC18E5.06

UCSC:P05764 rps21

Reference Transcript

RefSeq:NM_001021756.2 rps21

Participates

as a component of

40S ribosomal complex [cytosol] (Schizosaccharomyces pombe)

Other forms of this molecule

rps21 [nucleoplasm]

Inferred From

RPS21 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_595852.1

PRO

P05764

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