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XPA [nucleoplasm]
Stable Identifier
R-SPO-67437
Type
Protein [EntityWithAccessionedSequence]
Species
Schizosaccharomyces pombe
Compartment
nucleoplasm
Synonyms
O59753
Locations in the PathwayBrowser
Expand all
DNA Repair (Schizosaccharomyces pombe)
Nucleotide Excision Repair (Schizosaccharomyces pombe)
Global Genome Nucleotide Excision Repair (GG-NER) (Schizosaccharomyces pombe)
Dual Incision in GG-NER (Schizosaccharomyces pombe)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Schizosaccharomyces pombe)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Schizosaccharomyces pombe)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Schizosaccharomyces pombe)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Schizosaccharomyces pombe)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
Formation of Incision Complex in GG-NER (Schizosaccharomyces pombe)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Schizosaccharomyces pombe)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Schizosaccharomyces pombe)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Schizosaccharomyces pombe)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Schizosaccharomyces pombe)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Schizosaccharomyces pombe)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Schizosaccharomyces pombe)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
Formation of the pre-incision complex in GG-NER (Schizosaccharomyces pombe)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Schizosaccharomyces pombe)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
Recruitment of XPA and release of CAK (Schizosaccharomyces pombe)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
SUMOylation of XPC (Schizosaccharomyces pombe)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Schizosaccharomyces pombe)
Dual incision in TC-NER (Schizosaccharomyces pombe)
3' incision by ERCC5 (XPG) in TC-NER (Schizosaccharomyces pombe)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Schizosaccharomyces pombe)
TC-NER incision complex [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Schizosaccharomyces pombe)
TC-NER incision complex [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Schizosaccharomyces pombe)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)
TC-NER pre-incision complex [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
ERCC5 and RPA bind TC-NER site (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
Formation of TC-NER Pre-Incision Complex (Schizosaccharomyces pombe)
UVSSA:USP7 deubiquitinates ERCC6 (Schizosaccharomyces pombe)
TC-NER pre-incision complex [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Schizosaccharomyces pombe)
XPA [nucleoplasm] (Schizosaccharomyces pombe)
External Reference Information
External Reference
UniProt:O59753
Reference Genes
BioGPS Gene:2541120
ENSEMBL:SPBC649.03
KEGG:spo:SPBC649.03
Monarch:2541120
NCBI Gene:2541120
PomBase:SPBC649.03
UCSC:O59753
Reference Transcript
RefSeq:NM_001021128.2
Participates
as an output of
3' incision by ERCC5 (XPG) in TC-NER (Schizosaccharomyces pombe)
as a component of
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Schizosaccharomyces pombe)
TC-NER pre-incision complex [nucleoplasm] (Schizosaccharomyces pombe)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Schizosaccharomyces pombe)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Schizosaccharomyces pombe)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Schizosaccharomyces pombe)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Schizosaccharomyces pombe)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Schizosaccharomyces pombe)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Schizosaccharomyces pombe)
as an input of
Recruitment of XPA and release of CAK (Schizosaccharomyces pombe)
Inferred From
XPA [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_595222.1
PRO
O59753
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