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UBE2N:UBE2V2 [nucleoplasm]
Stable Identifier
R-SPO-5682542
Type
Complex
Species
Schizosaccharomyces pombe
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
DNA Repair (Schizosaccharomyces pombe)
DNA Double-Strand Break Repair (Schizosaccharomyces pombe)
DNA Double Strand Break Response (Schizosaccharomyces pombe)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Schizosaccharomyces pombe)
ATM phosphorylates TP53BP1 at DNA DSBs (Schizosaccharomyces pombe)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Schizosaccharomyces pombe)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
PPP5C dephosphorylates TP53BP1 (Schizosaccharomyces pombe)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
RNF8 and RNF168 ubiquitinate H2AFX (Schizosaccharomyces pombe)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
TP53BP1 associates with H4K20Me2 at DNA DSBs (Schizosaccharomyces pombe)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Schizosaccharomyces pombe)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Schizosaccharomyces pombe)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
Metabolism of proteins (Schizosaccharomyces pombe)
Post-translational protein modification (Schizosaccharomyces pombe)
Protein ubiquitination (Schizosaccharomyces pombe)
E3 ubiquitin ligases ubiquitinate target proteins (Schizosaccharomyces pombe)
SHPRH polyubiquitinates monoubiquitinated PCNA (Schizosaccharomyces pombe)
UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
spm2 [nucleoplasm]
(Schizosaccharomyces pombe)
ubc13 [nucleoplasm]
(Schizosaccharomyces pombe)
Participates
as an output of
SHPRH polyubiquitinates monoubiquitinated PCNA (Schizosaccharomyces pombe)
as an input of
HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Schizosaccharomyces pombe)
as a component of
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Schizosaccharomyces pombe)
Inferred From
UBE2N:UBE2V2 [nucleoplasm]
(Homo sapiens)
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