Reactome | POLK [nucleoplasm]

POLK [nucleoplasm]

Stable Identifier

R-SPO-5655487

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

nucleoplasm

Synonyms

O74944

Locations in the PathwayBrowser

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DNA Repair (Schizosaccharomyces pombe)

- DNA Damage Bypass (Schizosaccharomyces pombe)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Schizosaccharomyces pombe)
    - Termination of translesion DNA synthesis (Schizosaccharomyces pombe)
      - USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA polymerase Y [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA polymerase Y [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
      - USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Schizosaccharomyces pombe)
        
        DNA polymerase Y [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Schizosaccharomyces pombe)
        
        DNA polymerase Y [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
    - Translesion synthesis by POLK (Schizosaccharomyces pombe)
      - POLK and POLZ cooperate in elongation of mispaired primer termini (Schizosaccharomyces pombe)
        
        POLK:MonoUb:K164-PCNA:RPA:RFC:(Tg:A-mispaireddNMPs)-DNA Template,(OGUA:A-mispaireddNMPs)-DNA Template,(BPDE-G:C-mispaireddNMPs)-DNA Template [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK:Mg2+,Mn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK:Mg2+,Mn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
      - POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template (Schizosaccharomyces pombe)
        
        POLK:Mg2+,Mn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK:Mg2+,Mn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
      - POLK incorporates dNMP opposite to damaged DNA base (Schizosaccharomyces pombe)
        
        POLK:Mg2+,Mn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK:Mg2+,Mn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK:Mg2+,Mn2+ [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
- Nucleotide Excision Repair (Schizosaccharomyces pombe)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Schizosaccharomyces pombe)
    - Dual Incision in GG-NER (Schizosaccharomyces pombe)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Schizosaccharomyces pombe)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Schizosaccharomyces pombe)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLD,POLE,POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
    - Gap-filling DNA repair synthesis and ligation in GG-NER (Schizosaccharomyces pombe)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Schizosaccharomyces pombe)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Schizosaccharomyces pombe)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Schizosaccharomyces pombe)
    - Dual incision in TC-NER (Schizosaccharomyces pombe)
      - 3' incision by ERCC5 (XPG) in TC-NER (Schizosaccharomyces pombe)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Schizosaccharomyces pombe)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Schizosaccharomyces pombe)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Schizosaccharomyces pombe)
        
        POLD,POLE,POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Schizosaccharomyces pombe)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Schizosaccharomyces pombe)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Schizosaccharomyces pombe)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Schizosaccharomyces pombe)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Schizosaccharomyces pombe)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Schizosaccharomyces pombe)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Schizosaccharomyces pombe)
        
        (PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK) [nucleoplasm] (Schizosaccharomyces pombe)
        
        MonoUb:K164-PCNA homotrimer:POLK [nucleoplasm] (Schizosaccharomyces pombe)
        
        POLK [nucleoplasm] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:O74944

Reference Genes

BioGPS Gene:2539547

ENSEMBL:SPCC553.07c

KEGG:spo:SPCC553.07c

Monarch:2539547

NCBI Gene:2539547

PomBase:SPCC553.07c

UCSC:O74944

Reference Transcript

RefSeq:NM_001022760.2

Participates

as a member of

as a component of

Inferred From

POLK [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_587767.2

IntEnz

2.7.7.7

PRO

O74944

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