Reactome | phospho-hht1 [nucleoplasm]

phospho-hht1 [nucleoplasm]

Stable Identifier

R-SPO-5625754

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

nucleoplasm

Synonyms

p-T12, Me3K-10-HIST2H3A, P09988

Locations in the PathwayBrowser

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Signal Transduction (Schizosaccharomyces pombe)

- Signaling by Rho GTPases (Schizosaccharomyces pombe)
  - RHO GTPase Effectors (Schizosaccharomyces pombe)
    - RHO GTPases activate PKNs (Schizosaccharomyces pombe)
      - Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Schizosaccharomyces pombe)
        
        Demethylase KDM4C binds KLK2 and KLK3 promoters (Schizosaccharomyces pombe)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        phospho-hht1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        phospho-hht1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters (Schizosaccharomyces pombe)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4C [nucleoplasm] (Schizosaccharomyces pombe)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        phospho-hht1 [nucleoplasm] (Schizosaccharomyces pombe)
        
        PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters (Schizosaccharomyces pombe)
        
        p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm] (Schizosaccharomyces pombe)
        
        phospho-hht1 [nucleoplasm] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:P09988

Gene Names

hht1

Reference Genes

BioGPS Gene:2539804 hht1

BioGPS Gene:2541220 hht1

BioGPS Gene:2542467 hht1

ENSEMBL:SPAC1834.04

GeneDB:SPAC1834.04

KEGG Gene (Sc):SPAC1834.04 hht1

KEGG Gene (Sc):SPBC1105.11c hht1

KEGG Gene (Sc):SPBC8D2.04 hht1

Monarch:2539804 hht1

Monarch:2541220 hht1

Monarch:2542467 hht1

NCBI Gene:2539804 hht1

NCBI Gene:2541220 hht1

NCBI Gene:2542467 hht1

Reference Transcript

Participant Of

hasComponent

Nucleosome with p-T12, Me3K-10-H3 [nucleoplasm]

Other forms of this molecule

hht1 [nucleoplasm]

phospho-hht1 [nucleoplasm]

hht1 [nucleoplasm]

Inferred From

p-T12, Me3K-10-HIST2H3A [nucleoplasm] (Homo sapiens)

p-T12, Me3K-10-H3 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

N6,N6,N6-trimethyl-L-lysine at 10 (in Homo sapiens)

Coordinate

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Name

O-phospho-L-threonine at 12 (in Homo sapiens)

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_595567.1, NP_596467.1, NP_594683.1

Target Pathogen

5b2801b3be737e35a6df0ddc, 5b2801b2be737e35a6dea9b5, 5b354852be737e166372eaa9, 57c08b76be737e1cc0a95c6a, 57c0aa24be737e1cc0a9c2e3, 57c0ab45be737e1cc0a9d2f0, 5b2801b2be737e35a6dea8d6, 5b2801b3be737e35a6df1873, 5b2801b3be737e35a6df0ac2, 5b2801b2be737e35a6dea64d, 5b2801b2be737e35a6de88ae, 57c0ab9bbe737e1cc0a9d7f0, 5b354852be737e166372e85a, 57c5e634be737e5a0cb4cb11

PRO

P09988

PDB

3G7L, 2DZE