Reactome | clc1 [cytosol]

clc1 [cytosol]

Stable Identifier

R-SPO-350828

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

cytosol

Synonyms

Clathrin light chain, Q9USP6

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Schizosaccharomyces pombe)

- Membrane Trafficking (Schizosaccharomyces pombe)
  - Clathrin-mediated endocytosis (Schizosaccharomyces pombe)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Schizosaccharomyces pombe)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Schizosaccharomyces pombe)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
    - BAR domain proteins recruit dynamin (Schizosaccharomyces pombe)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Schizosaccharomyces pombe)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Schizosaccharomyces pombe)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Schizosaccharomyces pombe)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Schizosaccharomyces pombe)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Schizosaccharomyces pombe)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
    - FCHo proteins bind nascent clathrin-coated pit (Schizosaccharomyces pombe)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Schizosaccharomyces pombe)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
      - clathrin:HSPA8:ADP [cytosol] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Schizosaccharomyces pombe)
      - Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
    - SNX9 recruits components of the actin polymerizing machinery (Schizosaccharomyces pombe)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Schizosaccharomyces pombe)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Schizosaccharomyces pombe)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Schizosaccharomyces pombe)
        
        Clathrin Triskelion [cytosol] (Schizosaccharomyces pombe)
        
        clc1 [cytosol] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:Q9USP6

Gene Names

clc1

Reference Genes

BioGPS Gene:2541305 clc1

ENSEMBL:SPBC9B6.08

GeneDB:SPBC9B6.08

KEGG Gene (Sc):SPBC9B6.08 clc1

Monarch:2541305 clc1

NCBI Gene:2541305 clc1

Reference Transcript

RefSeq:NM_001021650.2 clc1

Participant Of

hasComponent

Clathrin Triskelion [cytosol]

Other forms of this molecule

clc1 [cytosol]

clc1 [trans-Golgi network membrane]

clc1 [lysosomal membrane]

clc1 [endolysosome membrane]

clc1 [plasma membrane]

Inferred From

CLTA [cytosol] (Homo sapiens)

Clathrin light chains [cytosol] (Homo sapiens)

Clathrin light chain [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_595750.1

PRO

Q9USP6