Reactome | ste20 [cytosol]

ste20 [cytosol]

Stable Identifier

R-SPO-198632

Type

Protein [EntityWithAccessionedSequence]

Species

Schizosaccharomyces pombe

Compartment

cytosol

Synonyms

RICTOR, Q09743

Locations in the PathwayBrowser

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Cellular responses to stimuli (Schizosaccharomyces pombe)

- Cellular responses to mechanical stimuli (Schizosaccharomyces pombe)
  - Response of endothelial cells to shear stress (Schizosaccharomyces pombe)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Schizosaccharomyces pombe)
      - mTORC2 phosphorylates AKT1 on serine-473 (Schizosaccharomyces pombe)
        
        TORC2 complex [cytosol] (Schizosaccharomyces pombe)
        
        ste20 [cytosol] (Schizosaccharomyces pombe)

Gene expression (Transcription) (Schizosaccharomyces pombe)

- RNA Polymerase II Transcription (Schizosaccharomyces pombe)
  - Generic Transcription Pathway (Schizosaccharomyces pombe)
    - Transcriptional Regulation by TP53 (Schizosaccharomyces pombe)
      - Regulation of TP53 Activity (Schizosaccharomyces pombe)
        
        Regulation of TP53 Expression and Degradation (Schizosaccharomyces pombe)
        
        Regulation of TP53 Degradation (Schizosaccharomyces pombe)
        
        TORC2 complex phosphorylates SGK1 (Schizosaccharomyces pombe)
        
        TORC2 complex [cytosol] (Schizosaccharomyces pombe)
        
        ste20 [cytosol] (Schizosaccharomyces pombe)

Immune System (Schizosaccharomyces pombe)

- Adaptive Immune System (Schizosaccharomyces pombe)
  - Regulation of T cell activation by CD28 family (Schizosaccharomyces pombe)
    - Co-stimulation by CD28 (Schizosaccharomyces pombe)
      - CD28 dependent PI3K/Akt signaling (Schizosaccharomyces pombe)
        
        TORC2 (mTOR) phosphorylates AKT at S473 (Schizosaccharomyces pombe)
        
        TORC2 complex [cytosol] (Schizosaccharomyces pombe)
        
        ste20 [cytosol] (Schizosaccharomyces pombe)

External Reference Information

External Reference

UniProt:Q09743

Gene Names

ste20

Reference Genes

BioGPS Gene:2539845 ste20

ENSEMBL:SPBC12C2.02c

KEGG:spo:2539845 ste20

Monarch:2539845 ste20

NCBI Gene:2539845 ste20

PomBase:SPBC12C2.02c

UCSC:Q09743 ste20

Reference Transcript

RefSeq:NM_001021929.2 ste20

Participates

as a component of

TORC2 complex [cytosol] (Schizosaccharomyces pombe)

Inferred From

RICTOR [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_596021.1

PRO

Q09743

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