GCN2:GCN1:80S ribosome:mRNA [cytosol]

Stable Identifier
R-SCE-9633561
Type
Complex
Species
Saccharomyces cerevisiae
Compartment
cytosol
Literature References
PubMed ID Title Journal Year
11101534 Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells

Sattlegger, E, Hinnebusch, AG

EMBO J. 2000
15722345 Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation

Hinnebusch, AG, Sattlegger, E

J. Biol. Chem. 2005
17202131 Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK

Dey, M, Cao, C, Dever, TE, Sicheri, F

J. Biol. Chem. 2007
10983975 Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

Anderson, J, Hinnebusch, AG, Dong, J, Garcia-Barrio, M, Qiu, H

Mol. Cell 2000
11250908 The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

Francklyn, CS, Hinnebusch, AG, Dong, J, Hu, C, Qiu, H

EMBO J. 2001
25437641 Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2

Sattlegger, E, Lee, SJ, Swanson, MJ

Biochem. J. 2015
10801780 GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast

Kubota, H, Sakaki, Y, Ito, T

J. Biol. Chem. 2000
7623840 The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

Wek, SA, Zhu, S, Wek, RC

Mol. Cell. Biol. 1995
24719324 Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals

Dey, S, Georgiadis, MM, Wek, RC, He, H, Baird, TD, Wek, SA, Singh, I

J. Biol. Chem. 2014
Participants
components
Participates
as an input of
Inferred To
EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
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