Reactome | UPF3 [cytosol]

UPF3 [cytosol]

Stable Identifier

R-SCE-927801

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

UPF3A, P48412

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)
        
        UPF3 [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)
        
        UPF3 [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Saccharomyces cerevisiae)
        
        UPF3 [cytosol] (Saccharomyces cerevisiae)
        
        UPF3 [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P48412

Gene Names

UPF3

Reference Genes

BioGPS Gene:852963 UPF3

ENSEMBL:YGR072W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YGR072W UPF3

Monarch:852963 UPF3

NCBI Gene:852963 UPF3

SGD:YGR072W

Reference Transcript

RefSeq:NM_001181201.1 UPF3

Other Identifiers

1775676_at

4953_at

852963

GO:0000184

GO:0003674

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005575

GO:0005634

GO:0005730

GO:0005737

GO:0005844

GO:0006310

GO:0006401

GO:0006417

GO:0008150

GO:0016567

GO:0045727

GO:0070478

GO:0070647

GO:0071026

Participates

as a component of

Other forms of this molecule

UPF3 [nucleoplasm]

UPF3 [cytosol]

Inferred From

UPF3AS-2 [cytosol] (Homo sapiens)

UPF3 [cytosol] (Homo sapiens)

UPF3A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_011586.1

PRO

P48412

Cite Us!