Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
UBI4(1-76) [cytosol]
Stable Identifier
R-SCE-9033758
Type
Protein [EntityWithAccessionedSequence]
Species
Saccharomyces cerevisiae
Compartment
cytosol
Synonyms
Polyubiquitin component recommendedName: Ubiquitin /component, UBI4P_YEAST, Ubiquitin
Locations in the PathwayBrowser for interactor UniProt:P40343 VPS27
Expand all
Autophagy (Saccharomyces cerevisiae)
Macroautophagy (Saccharomyces cerevisiae)
Selective autophagy (Saccharomyces cerevisiae)
Pexophagy (Saccharomyces cerevisiae)
ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Cell Cycle (Saccharomyces cerevisiae)
Cell Cycle Checkpoints (Saccharomyces cerevisiae)
G1/S DNA Damage Checkpoints (Saccharomyces cerevisiae)
p53-Independent G1/S DNA damage checkpoint (Saccharomyces cerevisiae)
p53-Independent DNA Damage Response (Saccharomyces cerevisiae)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Saccharomyces cerevisiae)
Proteolytic degradation of ubiquitinated-Cdc25A (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Cell Cycle, Mitotic (Saccharomyces cerevisiae)
Mitotic G2-G2/M phases (Saccharomyces cerevisiae)
G2/M Transition (Saccharomyces cerevisiae)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Saccharomyces cerevisiae)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Proteasome-mediated degradation of PolyUb-FBXL7 (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
SCF-FBXL18 ubiquitinates FBXL7 (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
SCF-FBXL7 ubiquitinates AURKA (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
S Phase (Saccharomyces cerevisiae)
Synthesis of DNA (Saccharomyces cerevisiae)
Switching of origins to a post-replicative state (Saccharomyces cerevisiae)
CDK-mediated phosphorylation and removal of Cdc6 (Saccharomyces cerevisiae)
Ubiquitinated Cdc6 is degraded by the proteasome (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Orc1 removal from chromatin (Saccharomyces cerevisiae)
Ubiquitinated Orc1 is degraded by the proteasome (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Cellular responses to stimuli (Saccharomyces cerevisiae)
Cellular responses to stress (Saccharomyces cerevisiae)
Cellular response to chemical stress (Saccharomyces cerevisiae)
KEAP1-NFE2L2 pathway (Saccharomyces cerevisiae)
ub UBXN7 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
DNA Replication (Saccharomyces cerevisiae)
Synthesis of DNA (Saccharomyces cerevisiae)
Switching of origins to a post-replicative state (Saccharomyces cerevisiae)
CDK-mediated phosphorylation and removal of Cdc6 (Saccharomyces cerevisiae)
Ubiquitinated Cdc6 is degraded by the proteasome (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Orc1 removal from chromatin (Saccharomyces cerevisiae)
Ubiquitinated Orc1 is degraded by the proteasome (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Immune System (Saccharomyces cerevisiae)
Adaptive Immune System (Saccharomyces cerevisiae)
Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
Antigen processing: Ubiquitination & Proteasome degradation (Saccharomyces cerevisiae)
E1 mediated ubiquitin activation (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Proteasomal cleavage of substrate (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Innate Immune System (Saccharomyces cerevisiae)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Saccharomyces cerevisiae)
Negative regulators of DDX58/IFIH1 signaling (Saccharomyces cerevisiae)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Metabolism (Saccharomyces cerevisiae)
Aerobic respiration and respiratory electron transport (Saccharomyces cerevisiae)
Pyruvate metabolism (Saccharomyces cerevisiae)
Regulation of pyruvate metabolism (Saccharomyces cerevisiae)
CTLH E3 ligase ubiquitinates PKM-1 (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Metabolism of proteins (Saccharomyces cerevisiae)
Post-translational protein modification (Saccharomyces cerevisiae)
Deubiquitination (Saccharomyces cerevisiae)
Ub-specific processing proteases (Saccharomyces cerevisiae)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Neddylation (Saccharomyces cerevisiae)
ub UBXN7 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Protein ubiquitination (Saccharomyces cerevisiae)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Saccharomyces cerevisiae)
UBA1 adenylates ubiquitin in the cytosol (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Signal Transduction (Saccharomyces cerevisiae)
Intracellular signaling by second messengers (Saccharomyces cerevisiae)
PIP3 activates AKT signaling (Saccharomyces cerevisiae)
PTEN Regulation (Saccharomyces cerevisiae)
Regulation of PTEN stability and activity (Saccharomyces cerevisiae)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
Proteasome degrades polyubiquitinated PTEN (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
MAPK family signaling cascades (Saccharomyces cerevisiae)
MAPK6/MAPK4 signaling (Saccharomyces cerevisiae)
MAPK6 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
UBI4(1-76) [cytosol] (Saccharomyces cerevisiae)
External Reference Information
External Reference
UniProt:P0CG63 UBI4
Gene Names
UBI4, SCD2, YLL039C
Chain
chain:1-76, chain:77-152, chain:153-228, chain:229-304, chain:305-380, propeptide:-
Reference Genes
BioGPS Gene:850620 UBI4
KEGG:sce:YLL039C UBI4
Monarch:850620 UBI4
NCBI Gene:850620 UBI4
UCSC:P0CG63 UBI4
Reference Transcript
RefSeq:NM_001181859.1 UBI4
Other Identifiers
10392_at
1772373_at
850620
GO:0000209
GO:0003674
GO:0005515
GO:0005575
GO:0005634
GO:0005737
GO:0005777
GO:0005829
GO:0006513
GO:0008150
GO:0008152
GO:0016567
GO:0016579
GO:0019899
GO:0019941
GO:0030437
GO:0031386
GO:0031625
GO:0043008
GO:0043934
GO:0051321
GO:0051603
GO:0070647
Participates
as an output of
MAPK6 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin (Saccharomyces cerevisiae)
ub UBXN7 is degraded by the 26S proteasome (Saccharomyces cerevisiae)
Proteasome-mediated degradation of PolyUb-FBXL7 (Saccharomyces cerevisiae)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Saccharomyces cerevisiae)
Ubiquitinated Orc1 is degraded by the proteasome (Saccharomyces cerevisiae)
Ubiquitinated Cdc6 is degraded by the proteasome (Saccharomyces cerevisiae)
Proteolytic degradation of ubiquitinated-Cdc25A (Saccharomyces cerevisiae)
Proteasome degrades polyubiquitinated PTEN (Saccharomyces cerevisiae)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Saccharomyces cerevisiae)
Proteasomal cleavage of substrate (Saccharomyces cerevisiae)
as a component of
Ub:PEX5 [cytosol] (Saccharomyces cerevisiae)
Ub:PEX5 [peroxisomal membrane] (Saccharomyces cerevisiae)
Ub:PEX5L [cytosol] (Saccharomyces cerevisiae)
UCHL1,UCHL3:Ub [cytosol] (Saccharomyces cerevisiae)
Ub:E2 (UBA1 substrate) [cytosol] (Saccharomyces cerevisiae)
Ub-Cys632-UBA1 [cytosol] (Saccharomyces cerevisiae)
Ub:PEX5L [peroxisomal membrane] (Saccharomyces cerevisiae)
Ub:UBE2N [cytosol] (Saccharomyces cerevisiae)
Ub:UBE2D1,2,3 [cytosol] (Saccharomyces cerevisiae)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [cytosol] (Saccharomyces cerevisiae)
Ub-unfolded protein:(GlcNAc)2 (Man)9-5 [endoplasmic reticulum quality control compartment] (Saccharomyces cerevisiae)
K63 linked polyubiquitin chain [cytosol] (Saccharomyces cerevisiae)
ubiquitinated Cdc6 [cytosol] (Saccharomyces cerevisiae)
Ub-p-S124-CDC25A [cytosol] (Saccharomyces cerevisiae)
UBE2D1,2,3:Ubiquitin [cytosol] (Saccharomyces cerevisiae)
E1 bound ubiquitin [cytosol] (Saccharomyces cerevisiae)
Ubiquitin:E2 conjugating enzymes [cytosol] (Saccharomyces cerevisiae)
Ub:substrate [cytosol] (Saccharomyces cerevisiae)
Ub:Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Saccharomyces cerevisiae)
Ub:UBE2N:UBE2V1 [cytosol] (Saccharomyces cerevisiae)
as an input of
Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol (Saccharomyces cerevisiae)
UBA1 adenylates ubiquitin in the cytosol (Saccharomyces cerevisiae)
CTLH E3 ligase ubiquitinates PKM-1 (Saccharomyces cerevisiae)
SCF-FBXL7 ubiquitinates AURKA (Saccharomyces cerevisiae)
SCF-FBXL18 ubiquitinates FBXL7 (Saccharomyces cerevisiae)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Saccharomyces cerevisiae)
E1 mediated ubiquitin activation (Saccharomyces cerevisiae)
ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5 (Saccharomyces cerevisiae)
Other forms of this molecule
UBI4 [cytosol]
UBI4 [cytosol]
UBI4 [nucleoplasm]
UBI4 [nucleoplasm]
UBI4 [nucleoplasm]
UBI4 [nucleoplasm]
UBI4 [cytosol]
UBI4 [nucleoplasm]
UBI4 [nucleoplasm]
UBI4 [nucleoplasm]
UBI4 [nucleoplasm]
UBI4 [cytosol]
UBI4 [cytosol]
UBI4 [cytosol]
UBI4 [cytosol]
UBI4 [cytosol]
UBI4 [endosome membrane]
phospho-UBI4 [cytosol]
UBI4 [cytosol]
phospho-UBI4 [nucleoplasm]
UBI4 [cytosol]
UBI4 [endocytic vesicle membrane]
Inferred From
Ub [cytosol]
(Homo sapiens)
UBA52(1-76) [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_013061.1
ENSEMBL
YLL039C
,
YLL039C_mRNA
PRO
P0CG63
PDB
1ZW7
,
4Q5E
,
3OLM
,
8DAT
,
4HCN
,
4NNJ
,
1OTR
,
2JWZ
,
2JT4
,
2KDI
,
2L00
,
8DAW
,
3L0W
,
8DAU
,
1WR1
,
3CMM
,
1Q0W
,
2G3Q
,
4Q5H
,
8DAV
,
3L10
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32628
2
RAD23 [nucleoplasm]
(R-SCE-62590)
RAD23 [nucleoplasm]
(R-SCE-5688076)
0.858
8
UniProt:P48510
2
DSK2 [cytosol]
(R-SCE-8866006)
DSK2 [cytosol]
(R-SCE-8866007)
0.766
7
UniProt:P40087 DDI1
0.658
3
UniProt:P40343 VPS27
0.618
5
UniProt:P15108
6
HSP90AA1 [ficolin-1-rich granule lumen]
(R-SCE-6801470-2)
HSP90AA1 [extracellular region]
(R-SCE-3221946-2)
HSP90AA1 [secretory granule lumen]
(R-SCE-6801515-2)
HSP90AA1 [plasma membrane]
(R-SCE-534996-2)
HSP90AA1 [nucleoplasm]
(R-SCE-5082401-2)
HSP90AA1 [cytosol]
(R-SCE-192864-2)
0.609
3
UniProt:P23301
3
HYP2 [cytosol]
(R-SCE-204650-2)
HYP2 [cytosol]
(R-SCE-204612-2)
HYP2 [cytosol]
(R-SCE-3149584-2)
0.609
2
UniProt:P54787
6
VPS9 [cytosol]
(R-SCE-8875290)
VPS9 [cytosol]
(R-SCE-8875419)
VPS9 [cytosol]
(R-SCE-8875287)
VPS9 [cytosol]
(R-SCE-8875293)
VPS9 [cytosol]
(R-SCE-8875292)
VPS9 [cytosol]
(R-SCE-8871123)
0.527
2
UniProt:P48365
2
GYP7 [cytosol]
(R-SCE-8854150)
GYP7 [autophagosome]
(R-SCE-8854607)
0.524
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text