Reactome | Me3K525-EEF2 [cytosol]

Me3K525-EEF2 [cytosol]

Stable Identifier

R-SCE-8932237

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

P32324

Locations in the PathwayBrowser for interactor UniProt:P52286

Expand all

External Reference Information

External Reference

UniProt:P32324 EFT1

Gene Names

EFT1, YOR133W, O3317, YOR3317W, EFT2, YDR385W

Chain

chain:1-842

Reference Genes

BioGPS Gene:851993 EFT1

BioGPS Gene:854301 EFT1

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDR385W EFT1

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YOR133W EFT1

Monarch:851993 EFT1

Monarch:854301 EFT1

NCBI Gene:851993 EFT1

NCBI Gene:854301 EFT1

Reference Transcript

Other Identifiers

1777413_s_at

8425_s_at

851993

854301

GO:0000166

GO:0003674

GO:0003723

GO:0003746

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005737

GO:0005829

GO:0006412

GO:0006414

GO:0006417

GO:0008135

GO:0008150

GO:0016787

GO:0019843

GO:0042802

GO:0043022

GO:0043167

GO:0045901

GO:0051087

GO:1990145

GO:1990904

Participates

as an output of

EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2 (Saccharomyces cerevisiae)

Other forms of this molecule

diphthine EFT1 [cytosol]

Me-diphthine EFT1 [cytosol]

diphthine EEF2 [cytosol]

nascent EEF2 [cytosol]

Me-diphthine EEF2 [cytosol]

aminocarboxypropyl EEF2 [cytosol]

EEF2 [cytosol]

EEF2 [secretory granule lumen]

EEF2 [ficolin-1-rich granule lumen]

EEF2 [extracellular region]

Inferred From

Me3K525-EEF2 [cytosol] (Homo sapiens)

Modified Residues

Name

dipthamide at 715 (in Homo sapiens)

Coordinate

715

PsiMod Name

dipthamide

PsiMod Definition

A protein modification that effectively converts an L-histidine residue to diphthamide.

Name

N6,N6,N6-trimethyl-L-lysine at 525 (in Homo sapiens)

Coordinate

525

PsiMod Name

N6,N6,N6-trimethyl-L-lysine [MOD:00083]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Cross References

RefSeq

NP_014776.1, NP_010673.1

PRO

P32324

PDB

8EVQ, 2ZIT, 3B78, 6GQB, 1N0U, 8EUB, 2NPF, 5JUS, 1ZM2, 8EVR, 8EVS, 3B8H, 2E1R, 2P8Z, 2P8Y, 5JUT, 2P8X, 2P8W, 8EWB, 6GQV, 5JUO, 1ZM9, 5JUU, 3B82, 6GQ1, 3DNY, 1N0V, 5JUP, 4V4B, 1U2R, 1ZM4, 1ZM3

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48362 HGH1			0.78	9
UniProt:P40487	1	DPH1 [cytosol] (R-SCE-5358384)	0.704	25
UniProt:P32461	1	DPH2 [cytosol] (R-SCE-5358368)	0.678	27
UniProt:P32324 EFT1	11	Me3K525-EEF2 [cytosol] (R-SCE-8932237) diphthine EFT1 [cytosol] (R-SCE-5367015) Me-diphthine EFT1 [cytosol] (R-SCE-5367013) diphthine EEF2 [cytosol] (R-SCE-5358501) nascent EEF2 [cytosol] (R-SCE-5358472) Me-diphthine EEF2 [cytosol] (R-SCE-5367025) aminocarboxypropyl EEF2 [cytosol] (R-SCE-5358478) EEF2 [cytosol] (R-SCE-156901) EEF2 [secretory granule lumen] (R-SCE-6801504) EEF2 [ficolin-1-rich granule lumen] (R-SCE-6801513) EEF2 [extracellular region] (R-SCE-6806499)	0.678	59
UniProt:P42842 EMW1			0.659	5
UniProt:P05317	1	RPP0 [cytosol] (R-SCE-72396)	0.622	3
UniProt:P32469	1	DPH5 [cytosol] (R-SCE-5358485)	0.595	3
UniProt:Q02821	2	SRP1 [cytosol] (R-SCE-180612) SRP1 [cytosol] (R-SCE-9734672)	0.564	2
UniProt:P40150	17	HSPA6 [cytosol] (R-SCE-3371521-6) HSPA13 [cytosol] (R-SCE-5251981-6) HSPA14 [cytosol] (R-SCE-5251948-6) HSPA13 [nucleoplasm] (R-SCE-5252009-6) HSPA6 [nucleoplasm] (R-SCE-5252088-6) HSPA14 [nucleoplasm] (R-SCE-5252082-6) HSPA1L [nucleoplasm] (R-SCE-5082367-6) HSPA2 [nucleoplasm] (R-SCE-912480-6) HSPA1A [nucleoplasm] (R-SCE-6792605-6) HSPA6 [secretory granule lumen] (R-SCE-6801472-6) HSPA6 [extracellular region] (R-SCE-6806500-6) HSPA1A [extracellular region] (R-SCE-6805872-6) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-6) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-6) HSPA1A [cytosol] (R-SCE-6792602-6) HSPA2 [cytosol] (R-SCE-3371408-6) HSPA1L [cytosol] (R-SCE-3371410-6)	0.564	2
UniProt:P41940 MPG1			0.547	2
UniProt:P32905 RPS0A	3	RPS0A [nucleoplasm] (R-SCE-6798722) RPS0A [cytosol] (R-SCE-9633103) RPS0A [cytosol] (R-SCE-72389)	0.528	2
UniProt:P38011	1	ASC1 [cytosol] (R-SCE-5626956)	0.528	2
UniProt:P40413	1	CCT5 [cytosol] (R-SCE-390447)	0.527	3
UniProt:P10591	17	SSA1 [cytosol] (R-SCE-3371410-2) SSA1 [cytosol] (R-SCE-3371408-2) SSA1 [cytosol] (R-SCE-6792602-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801512-2) SSA1 [ficolin-1-rich granule lumen] (R-SCE-6801496-2) SSA1 [extracellular region] (R-SCE-6805872-2) SSA1 [extracellular region] (R-SCE-6806500-2) SSA1 [secretory granule lumen] (R-SCE-6801472-2) SSA1 [nucleoplasm] (R-SCE-6792605-2) SSA1 [nucleoplasm] (R-SCE-912480-2) SSA1 [nucleoplasm] (R-SCE-5082367-2) SSA1 [nucleoplasm] (R-SCE-5252082-2) SSA1 [nucleoplasm] (R-SCE-5252088-2) SSA1 [nucleoplasm] (R-SCE-5252009-2) SSA1 [cytosol] (R-SCE-5251948-2) SSA1 [cytosol] (R-SCE-5251981-2) SSA1 [cytosol] (R-SCE-3371521-2)	0.527	3
UniProt:Q00362	2	CDC55 [cytosol] (R-SCE-377253) CDC55 [nucleoplasm] (R-SCE-1564978)	0.527	2
UniProt:Q03330	2	KAT2B [nucleoplasm] (R-SCE-352430) KAT2A [nucleoplasm] (R-SCE-3006516)	0.527	3
UniProt:P39077	1	CCT3 [cytosol] (R-SCE-390463)	0.527	3
UniProt:P35184	1	SQT1 [cytosol] (R-SCE-9674636)	0.527	3
UniProt:P25491	3	SOH-C149,C150-DNAJA1 [cytosol] (R-SCE-9857072) DNAJA4 [cytosol] (R-SCE-3371578) DNAJA2 [cytosol] (R-SCE-3371555)	0.527	4
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [cytosol] (R-SCE-5251948-3)	0.527	3
UniProt:P52286	2	SKP1 [cytosol] (R-SCE-174150) SKP1 [nucleoplasm] (R-SCE-187538)	0.499	2
UniProt:P14120 RPL30	2	RPL30 [cytosol] (R-SCE-9633100) RPL30 [cytosol] (R-SCE-72452)	0.46	2

Cite Us!