Reactome | RPL2B [cytosol]

RPL2B [cytosol]

Stable Identifier

R-SCE-72490-2

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

RPL8, P0CX46

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL8 [cytosol] (Saccharomyces cerevisiae)
        
        RPL2B [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL8 [cytosol] (Saccharomyces cerevisiae)
        
        RPL2B [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL8 [cytosol] (Saccharomyces cerevisiae)
        
        RPL2B [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL8 [cytosol] (Saccharomyces cerevisiae)
        
        RPL2B [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        Homologues of RPL8 [cytosol] (Saccharomyces cerevisiae)
        
        RPL2B [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P0CX46 RPL2B

Gene Names

RPL2B, RPL5A, YIL018W

Chain

initiator methionine:, chain:2-254

Reference Genes

BioGPS Gene:850590 RPL2B

BioGPS Gene:854794 RPL2B

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YFR031C-A RPL2B

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YIL018W RPL2B

Monarch:850590 RPL2B

Monarch:854794 RPL2B

NCBI Gene:850590 RPL2B

NCBI Gene:854794 RPL2B

Reference Transcript

Other Identifiers

1773091_at

1776370_at

1780178_s_at

5329_s_at

850590

854794

GO:0002181

GO:0003674

GO:0003723

GO:0003735

GO:0005198

GO:0005575

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0008150

GO:0019843

GO:0022625

GO:1990904

Participates

as a member of

Homologues of RPL8 [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

RPL2B [nucleoplasm]

RPL2B [cytosol]

Inferred From

RPL8 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_012246.1, NP_116688.3

PRO

P0CX46

PDB

4V8Y, 4V8T, 4V8Z

Cite Us!