Reactome | RPP2A [cytosol]

RPP2A [cytosol]

Stable Identifier

R-SCE-72400

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

RPLP2, P05319

Locations in the PathwayBrowser

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Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPP2A [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPP2A [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPP2A [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPP2A [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        60S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPP2A [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P05319

Gene Names

RPP2A

Reference Genes

BioGPS Gene:854118 RPP2A

ENSEMBL:YOL039W

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YOL039W RPP2A

Monarch:854118 RPP2A

NCBI Gene:854118 RPP2A

SGD:YOL039W

Reference Transcript

RefSeq:NM_001183293.1 RPP2A

Other Identifiers

1774473_at

854118

8613_at

GO:0002181

GO:0002182

GO:0003674

GO:0003735

GO:0005198

GO:0005515

GO:0005575

GO:0005737

GO:0005840

GO:0006414

GO:0008150

GO:0022625

GO:0030234

GO:0030295

GO:1990904

Participates

as a component of

Inferred From

RPLP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_014603.1

PRO

P05319

PDB

4V6I

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