Reactome | RPS0A [cytosol]

RPS0A [cytosol]

Stable Identifier

R-SCE-72389

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

cytosol

Synonyms

RPSA, P32905

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Saccharomyces cerevisiae)

- Nonsense-Mediated Decay (NMD) (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Saccharomyces cerevisiae)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        40S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPS0A [cytosol] (Saccharomyces cerevisiae)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        40S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPS0A [cytosol] (Saccharomyces cerevisiae)
    - SMG6 hydrolyzes mRNA with premature termination codon (Saccharomyces cerevisiae)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        40S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPS0A [cytosol] (Saccharomyces cerevisiae)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Saccharomyces cerevisiae)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Saccharomyces cerevisiae)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        40S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPS0A [cytosol] (Saccharomyces cerevisiae)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Saccharomyces cerevisiae)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Saccharomyces cerevisiae)
        
        80S ribosome [cytosol] (Saccharomyces cerevisiae)
        
        40S ribosomal complex [cytosol] (Saccharomyces cerevisiae)
        
        RPS0A [cytosol] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P32905 RPS0A

Gene Names

RPS0A, NAB1, NAB1A, YST1, YGR214W

Chain

initiator methionine:, chain:2-252

Reference Genes

BioGPS Gene:853128 RPS0A

KEGG:sce:YGR214W RPS0A

Monarch:853128 RPS0A

NCBI Gene:853128 RPS0A

UCSC:P32905 RPS0A

Reference Transcript

RefSeq:NM_001181343.1 RPS0A

Other Identifiers

10302_g_at

1770653_at

4779_f_at

4780_at

853128

GO:0000028

GO:0000447

GO:0000461

GO:0002181

GO:0003674

GO:0003735

GO:0005198

GO:0005575

GO:0005737

GO:0005829

GO:0005840

GO:0006364

GO:0006407

GO:0006412

GO:0008150

GO:0010494

GO:0015931

GO:0015935

GO:0022627

GO:0030686

GO:0042254

GO:0042255

GO:0042274

GO:0051169

GO:0070925

GO:1990904

Participates

as a component of

40S ribosomal complex [cytosol] (Saccharomyces cerevisiae)

Other forms of this molecule

RPS0A [cytosol]

RPS0A [nucleoplasm]

Inferred From

RPSA [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_011730.1

ENSEMBL

YGR214W, YGR214W_mRNA

PRO

P32905

PDB

4U4R, 5NDG, 8CAH, 7NRD, 4V7R, 4U4N, 6T83, 6GQB, 4U3N, 8C01, 8C83, 5TGA, 5DGE, 6GQV, 6WDR, 6Z6J, 6TNU, 5MEI, 4U4Y, 6SNT, 6TB3, 6ZVI, 5JUT, 8EWC, 5NDW, 5DC3, 5ON6, 7B7D, 3J78, 6XIR, 5LYB, 4U4Q, 7MPI, 4U4O, 7MPJ, 8CEH, 6RBE, 8EUB, 5DGV, 6T7I, 5FCJ, 7ZPQ, 5DGF, 4V8Y, 4U53, 8CGN, 8CCS, 8CKU, 6S47, 8BQD, 3J77, 4U4Z, 5JUO, 8CMJ, 5TGM, 4U4U, 5MC6, 3J6X, 5JUP, 8EVQ, 5OBM, 6SV4, 4U52, 7N8B, 8CIV, 4U50, 8CG8, 5M1J, 5TBW, 4U3M, 6ZCE, 8CDL, 4U6F, 6EML, 4V4B, 6HHQ, 4V88, 7ZUX, 8CF5, 6Y7C, 3J6Y, 5JUS, 4V92, 8EVP, 6GQ1, 4U56, 6XIQ, 5NDV, 8EVS, 7ZW0, 4U51, 4V6I, 6RBD, 6T4Q, 7NRC, 7A1G, 5FCI, 8CDR, 5I4L, 4V8Z, 8CAS, 8BN3, 6Z6K, 8BQX, 5DAT, 6T7T, 6FAI, 7ZUW, 5LL6, 6ZU9, 5JUU, 6I7O, 8Y0U, 8EWB, 4U3U, 8CBJ, 7ZRS, 8EVR, 6Q8Y, 8EVT, 4U55

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32324 EFT1	11	EEF2 [secretory granule lumen] (R-SCE-6801504) EEF2 [extracellular region] (R-SCE-6806499) EEF2 [ficolin-1-rich granule lumen] (R-SCE-6801513) EEF2 [cytosol] (R-SCE-156901) aminocarboxypropyl EEF2 [cytosol] (R-SCE-5358478) Me-diphthine EEF2 [cytosol] (R-SCE-5367025) nascent EEF2 [cytosol] (R-SCE-5358472) diphthine EEF2 [cytosol] (R-SCE-5358501) Me-diphthine EFT1 [cytosol] (R-SCE-5367013) diphthine EFT1 [cytosol] (R-SCE-5367015) Me3K525-EEF2 [cytosol] (R-SCE-8932237)	0.528	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [cytosol] (R-SCE-5251948-3)	0.527	2

Cite Us!