Reactome | CLB1 [nucleoplasm]

CLB1 [nucleoplasm]

Stable Identifier

R-SCE-68905-4

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

CCNA2, P24868

Locations in the PathwayBrowser

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DNA Replication (Saccharomyces cerevisiae)

- Synthesis of DNA (Saccharomyces cerevisiae)
  - Switching of origins to a post-replicative state (Saccharomyces cerevisiae)
    - CDK-mediated phosphorylation and removal of Cdc6 (Saccharomyces cerevisiae)
      - Cdc6 protein is phosphorylated by CDK (Saccharomyces cerevisiae)
        
        CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CCNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of CCNA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CLB1 [nucleoplasm] (Saccharomyces cerevisiae)
    - Orc1 removal from chromatin (Saccharomyces cerevisiae)
      - Orc1 is phosphorylated by cyclin A/CDK2 (Saccharomyces cerevisiae)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CCNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of CCNA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CLB1 [nucleoplasm] (Saccharomyces cerevisiae)

Gene expression (Transcription) (Saccharomyces cerevisiae)

- RNA Polymerase II Transcription (Saccharomyces cerevisiae)
  - Generic Transcription Pathway (Saccharomyces cerevisiae)
    - Transcriptional Regulation by TP53 (Saccharomyces cerevisiae)
      - Regulation of TP53 Activity (Saccharomyces cerevisiae)
        
        Regulation of TP53 Expression and Degradation (Saccharomyces cerevisiae)
        
        Regulation of TP53 Degradation (Saccharomyces cerevisiae)
        
        (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Saccharomyces cerevisiae)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CCNA [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of CCNA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CLB1 [nucleoplasm] (Saccharomyces cerevisiae)

Metabolism of proteins (Saccharomyces cerevisiae)

- Post-translational protein modification (Saccharomyces cerevisiae)
  - Deubiquitination (Saccharomyces cerevisiae)
    - Ub-specific processing proteases (Saccharomyces cerevisiae)
      - USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2 (Saccharomyces cerevisiae)
        
        USP37:RUVLB1:PSMC5:CCNA1,CCNA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CCNA1,CCNA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of CCNA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        CLB1 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P24868

Gene Names

CLB1

Reference Genes

BioGPS Gene:853002 CLB1

ENSEMBL:YGR108W

KEGG Gene (Saccharomyces cerevisiae (strain YJM789)):YGR108W CLB1

Monarch:853002 CLB1

NCBI Gene:853002 CLB1

SGD:YGR108W

Reference Transcript

RefSeq:NM_001181237.1 CLB1

Other Identifiers

1769973_at

4898_at

853002

GO:0000079

GO:0000086

GO:0000278

GO:0000307

GO:0003674

GO:0005575

GO:0005634

GO:0005737

GO:0006468

GO:0007010

GO:0007059

GO:0008150

GO:0010696

GO:0016538

GO:0030234

GO:0030472

GO:0031399

GO:0033043

GO:0048285

GO:0051301

GO:0051321

GO:0051726

GO:0060631

GO:0070925

Participates

as a member of

Homologues of CCNA2 [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

CLB1 [nucleoplasm]

CLB1 [cytosol]

phospho-CLB1 [cytosol]

phospho-CLB1 [nucleoplasm]

CLB1 [cytosol]

CLB1 [nucleoplasm]

CLB1 [cytosol]

CLB1 [nucleoplasm]

CLB1 [cytosol]

Inferred From

CCNA2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_011622.1

PRO

P24868

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00546	11	CDC28 [nucleoplasm] (R-SCE-68365) phospho-CDC28 [nucleoplasm] (R-SCE-187967) phospho-CDC28 [nucleoplasm] (R-SCE-187905) CDC28 [cytosol] (R-SCE-157440) phospho-CDC28 [nucleoplasm] (R-SCE-69628) phospho-CDC28 [nucleoplasm] (R-SCE-113830) CDC28 [nucleoplasm] (R-SCE-141283) CDC28 [nucleoplasm] (R-SCE-113843) CDC28 [cytosol] (R-SCE-68336) CDC28 [cytosol] (R-SCE-68330) phospho-CDC28 [nucleoplasm] (R-SCE-68370)	0.462	2

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