Reactome | ORC1 [nucleoplasm]

ORC1 [nucleoplasm]

Stable Identifier

R-SCE-68522

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

P54784

Locations in the PathwayBrowser for interactor UniProt:P04912

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External Reference Information

External Reference

UniProt:P54784 ORC1

Gene Names

ORC1, YML065W

Chain

chain:1-914

Reference Genes

BioGPS Gene:854937 ORC1

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YML065W ORC1

Monarch:854937 ORC1

NCBI Gene:854937 ORC1

Reference Transcript

RefSeq:NM_001182424.1 ORC1

Other Identifiers

1770816_at

854937

9689_at

GO:0000166

GO:0000278

GO:0003674

GO:0003677

GO:0003682

GO:0003688

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005654

GO:0005656

GO:0005664

GO:0005694

GO:0006260

GO:0006267

GO:0006270

GO:0006325

GO:0008150

GO:0016787

GO:0016887

GO:0023052

GO:0030466

GO:0031261

GO:0031491

GO:0032993

GO:0033314

GO:0043007

GO:0043167

GO:0046872

GO:0051726

GO:0140657

Participates

as an input of

ORC1 binds to H4K20me2 (Saccharomyces cerevisiae)

as an output of

ORC1 translocates to the nucleus (Saccharomyces cerevisiae)

as a component of

Other forms of this molecule

yORC1 [nucleoplasm]

ORC1 [cytosol]

phospho-p-S,T-ORC1 [nucleoplasm]

phospho-PolyUb,p-S,T-ORC1 [nucleoplasm]

phospho-PolyUb,p-S,T-ORC1 [cytosol]

Inferred From

ORC1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_013646.1

OpenTargets

ENSG00000085840

PRO

P54784

PDB

6RQC, 7TJK, 6WGG, 7TJF, 7TJJ, 1ZHI, 7TJI, 6WGC, 5V8F, 7E9F, 7MCA, 1M4Z, 6OM3, 7TJH, 6WGI, 5ZR1, 7E9C, 1ZBX

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54791 ORC4	2	yORC4 [nucleoplasm] (R-SCE-9749319) ORC4 [nucleoplasm] (R-SCE-68519)	0.87	19
UniProt:P38826 ORC6	1	yORC6 [nucleoplasm] (R-SCE-9749321)	0.803	18
UniProt:P32833 ORC2	2	yORC2 [nucleoplasm] (R-SCE-9749316) ORC2 [nucleoplasm] (R-SCE-68405)	0.767	19
UniProt:P54790 ORC3	2	yORC3 [nucleoplasm] (R-SCE-9749325) ORC3 [nucleoplasm] (R-SCE-68513)	0.767	11
UniProt:P50874 ORC5	2	yORC5 [nucleoplasm] (R-SCE-9749322) ORC5 [nucleoplasm] (R-SCE-68516)	0.767	11
UniProt:P09119 CDC6	5	CDC6 [cytosol] (R-SCE-113566) phospho-p-CDC6 [cytosol] (R-SCE-68583) phospho-p-CDC6 [nucleoplasm] (R-SCE-5661317) yCDC6 [nucleoplasm] (R-SCE-9749328) CDC6 [nucleoplasm] (R-SCE-68542)	0.652	3
UniProt:P02309	14	HHF2 [nucleoplasm] (R-SCE-4570518) HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-4568744) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-5423110) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-5651652) HHF2 [nucleoplasm] (R-SCE-181902)	0.564	2
UniProt:P02294	16	HTB2 [nucleoplasm] (R-SCE-181898-2) HTB2 [nucleoplasm] (R-SCE-181916-2) HTB2 [nucleoplasm] (R-SCE-3364019-2) HTB2 [nucleoplasm] (R-SCE-3364020-2) HTB2 [nucleoplasm] (R-SCE-4568637-2) HTB2 [nucleoplasm] (R-SCE-4568639-2) HTB2 [nucleoplasm] (R-SCE-4568629-2) HTB2 [nucleoplasm] (R-SCE-4568632-2) HTB2 [nucleoplasm] (R-SCE-4568647-2) HTB2 [nucleoplasm] (R-SCE-4568631-2) HTB2 [nucleoplasm] (R-SCE-4568615-2) HTB2 [nucleoplasm] (R-SCE-4568624-2) HTB2 [nucleoplasm] (R-SCE-4549272-2) HTB2 [nucleoplasm] (R-SCE-4549263-2) HTB2 [nucleoplasm] (R-SCE-6782554-2) HTB2 [nucleoplasm] (R-SCE-6782561-2)	0.564	3
UniProt:Q96EY1-3 DNAJA3			0.556	3
UniProt:P11484	17	HSPA1L [cytosol] (R-SCE-3371410-4) HSPA2 [cytosol] (R-SCE-3371408-4) HSPA1A [cytosol] (R-SCE-6792602-4) HSPA6 [ficolin-1-rich granule lumen] (R-SCE-6801512-4) HSPA1A [ficolin-1-rich granule lumen] (R-SCE-6801496-4) HSPA1A [extracellular region] (R-SCE-6805872-4) HSPA6 [extracellular region] (R-SCE-6806500-4) HSPA6 [secretory granule lumen] (R-SCE-6801472-4) HSPA1A [nucleoplasm] (R-SCE-6792605-4) HSPA2 [nucleoplasm] (R-SCE-912480-4) HSPA1L [nucleoplasm] (R-SCE-5082367-4) HSPA14 [nucleoplasm] (R-SCE-5252082-4) HSPA6 [nucleoplasm] (R-SCE-5252088-4) HSPA13 [nucleoplasm] (R-SCE-5252009-4) HSPA14 [cytosol] (R-SCE-5251948-4) HSPA13 [cytosol] (R-SCE-5251981-4) HSPA6 [cytosol] (R-SCE-3371521-4)	0.527	2
UniProt:P21691 SIR1			0.527	3
UniProt:P04912	20	HTA2 [nucleoplasm] (R-SCE-6782532-2) HTA2 [nucleoplasm] (R-SCE-6782493-2) HTA2 [nucleoplasm] (R-SCE-6782514-2) HTA2 [nucleoplasm] (R-SCE-6782531-2) HTA2 [nucleoplasm] (R-SCE-4568572-2) HTA2 [nucleoplasm] (R-SCE-4568611-2) HTA2 [nucleoplasm] (R-SCE-4568583-2) HTA2 [nucleoplasm] (R-SCE-4568598-2) HTA2 [nucleoplasm] (R-SCE-5244584-2) HTA2 [nucleoplasm] (R-SCE-5244581-2) HTA2 [nucleoplasm] (R-SCE-5244538-2) HTA2 [nucleoplasm] (R-SCE-5244562-2) HTA2 [nucleoplasm] (R-SCE-5244557-2) HTA2 [nucleoplasm] (R-SCE-5244574-2) HTA2 [nucleoplasm] (R-SCE-5244542-2) HTA2 [nucleoplasm] (R-SCE-5244576-2) HTA2 [nucleoplasm] (R-SCE-5244590-2) HTA2 [nucleoplasm] (R-SCE-5244621-2) HTA2 [nucleoplasm] (R-SCE-5244589-2) HTA2 [nucleoplasm] (R-SCE-5244628-2)	0.527	2
UniProt:P02293	16	HTB1 [nucleoplasm] (R-SCE-6782561) HTB1 [nucleoplasm] (R-SCE-6782554) HTB1 [nucleoplasm] (R-SCE-4549263) HTB1 [nucleoplasm] (R-SCE-4549272) HTB1 [nucleoplasm] (R-SCE-4568624) HTB1 [nucleoplasm] (R-SCE-181898) HTB1 [nucleoplasm] (R-SCE-181916) HTB1 [nucleoplasm] (R-SCE-3364019) HTB1 [nucleoplasm] (R-SCE-3364020) HTB1 [nucleoplasm] (R-SCE-4568637) HTB1 [nucleoplasm] (R-SCE-4568639) HTB1 [nucleoplasm] (R-SCE-4568629) HTB1 [nucleoplasm] (R-SCE-4568632) HTB1 [nucleoplasm] (R-SCE-4568647) HTB1 [nucleoplasm] (R-SCE-4568631) HTB1 [nucleoplasm] (R-SCE-4568615)	0.527	2

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