TRM9 methylates 5-carboxymethyluridine-34 in tRNA(Arg3) yielding 5-methoxycarbonylmethyluridine-34

Stable Identifier
R-SCE-6790171
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
cytoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TRM9 methylates 5-carboxymethyluridine-34 in tRNA(Arg3) yielding 5-methoxycarbonylmethyluridine-34
TRM9 transfers a methyl group from S-adenosylmethionine (AdoMet) to 5-carboxymethyluridine-34 of tRNA, yielding 5-methoxycarbonylmethyluridine-34 (5-(2-methoxy-2-oxoethyl)uridine-34) (Calhor and Clarke 2003).
Literature References
PubMed ID Title Journal Year
14645538 Novel methyltransferase for modified uridine residues at the wobble position of tRNA

Clarke, S, Kalhor, HR

Mol. Cell. Biol. 2003
Participants
Input
Output
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA methyltransferase activity of TRM9 [cytoplasm]

Physical Entity
TRM9 [cytoplasm] (Saccharomyces cerevisiae)
Activity
tRNA methyltransferase activity (GO:0008175)
Orthologous Events
ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34 (Homo sapiens)
Authored
May, B  (2015-08-08)
Reviewed
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-08-09)
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