SMM1 (DUS2) reduces uridine-20 to dihydrouridine in tRNA(Leu)

Stable Identifier
R-SCE-6790127
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
cytoplasm
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SMM1 (DUS2) reduces uridine-20 to dihydrouridine in tRNA(Leu)

SMM1 (DUS2) catalyzes the reduction of the 5,6 double bond in uridine residues in the D-loop of tRNA(Leu) (Xing et al. 2002, Xing et al. 2004), yielding 5,6-dihydrouridine. NADH or NADPH is the reducing agent. The subcellular location of the reaction is unknown.

Literature References
PubMed ID Title Journal Year
14970222 The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs

Phizicky, EM, Hiley, SL, Hughes, TR, Xing, F

J. Biol. Chem. 2004
12003496 A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA

Phizicky, EM, Martzen, MR, Xing, F

RNA 2002
Participants
Input
Output
Event Information
Go Biological Process
tRNA modification (0006400)
Catalyst Activity

tRNA dihydrouridine synthase activity of SMM1 [cytoplasm]

Physical Entity
SMM1 [cytoplasm] (Saccharomyces cerevisiae)
Activity
tRNA dihydrouridine synthase activity (GO:0017150)
Orthologous Events
DUS2:EPRS reduces uridine to dihydrouridine in tRNAs (Homo sapiens)
Authored
May, B  (2015-08-08)
Reviewed
Motorin, Y  (2015-08-25)
Jarrous, N  (2015-10-24)
Created
May, B  (2015-08-09)
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