SMM1 (DUS2) reduces uridine-20 to dihydrouridine in tRNA(Leu)

Stable Identifier
R-SCE-6790127
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
General
SVG |   | PPTX  | SBGN
SMM1 (DUS2) reduces uridine-20 to dihydrouridine in tRNA(Leu)

SMM1 (DUS2) catalyzes the reduction of the 5,6 double bond in uridine residues in the D-loop of tRNA(Leu) (Xing et al. 2002, Xing et al. 2004), yielding 5,6-dihydrouridine. NADH or NADPH is the reducing agent. The subcellular location of the reaction is unknown.

Literature References
PubMed ID Title Journal Year
12003496 A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA

Xing, F, Martzen, MR, Phizicky, EM

RNA 2002
14970222 The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs

Xing, F, Hiley, SL, Hughes, TR, Phizicky, EM

J. Biol. Chem. 2004
Participants
Event Information
Go Biological Process
Catalyst Activity

tRNA dihydrouridine synthase activity of SMM1 [cytoplasm]

Orthologous Events
Authored
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