Reactome | SLM3 (MTO2, MTU1) transfers a sulfur atom to 5-carboxymethylaminomethyluridine-34 in tRNA

SLM3 (MTO2, MTU1) transfers a sulfur atom to 5-carboxymethylaminomethyluridine-34 in tRNA

Stable Identifier

R-SCE-6787385

Type

Reaction [omitted]

Species

Saccharomyces cerevisiae

Compartment

mitochondrial matrix

ReviewStatus

5/5

General

SBML | | PDF

SVG | | PPTX | SBGN

SLM3 (MTO2, MTU1) transfers a sulfur atom to 5-carboxymethylaminomethyluridine-34 in tRNA

MTU1 transfers a sulfur atom from L-cysteine to the 2 position of 5-carboxymethylaminomethyluridine-34 in tRNAs (Umeda et al. 2005). In Escherichia coli the sulfur is transferred along a relay system of proteins from L-cysteine to uridine. It is unknown if such a relay system also exists in yeast. Mutations in MTU1 act synergistically with mutations in MSS1 (the homolog of GTPBP3) and MTO1 to impair mitochondrial function (Umeda et al. 2005, Wang et al. 2010). Deletion of MTU1 causes mitochondrial failure (Wang et al. 2007) and mutations in MTU1 modify the phenotype produced by mutations in mitochondrial 12S rRNA (Yan et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
20004207	Combination of the loss of cmnm5U34 with the lack of s2U34 modifications of tRNALys, tRNAGlu, and tRNAGln altered mitochondrial biogenesis and respiration Wang, X, Yan, Q, Guan, MX	J. Mol. Biol.	2010
15509579	Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases Umeda, N, Suzuki, T, Yukawa, M, Ohya, Y, Shindo, H, Watanabe, K, Suzuki, T	J. Biol. Chem.	2005
15944150	Mutations in MTO2 related to tRNA modification impair mitochondrial gene expression and protein synthesis in the presence of a paromomycin resistance mutation in mitochondrial 15 S rRNA Yan, Q, Li, X, Faye, G, Guan, MX	J. Biol. Chem.	2005
17706197	Deletion of the MTO2 gene related to tRNA modification causes a failure in mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae Wang, X, Yan, Q, Guan, MX	FEBS Lett.	2007

Participants

Input

Output

tRNA(Gln,Glu,Lys) containing 5-carboxymethylaminomethyl-2-thioU-34 [mitochondrial matrix] (Saccharomyces cerevisiae)

Event Information

Go Biological Process

tRNA modification (0006400)

Catalyst Activity

sulfurtransferase activity of SLM3 [mitochondrial matrix]

Physical Entity

SLM3 [mitochondrial matrix] (Saccharomyces cerevisiae)

Activity

sulfurtransferase activity (GO:0016783)

Orthologous Events

TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA (Homo sapiens)

Authored

May, B (2015-07-10)

Reviewed

Jarrous, N (2015-10-24)

Levinger, L (2015-08-11)

Motorin, Y (2015-08-25)

Powell, CA (2015-11-07)

Created

May, B (2015-07-13)

Cite Us!