Reactome | phospho-HTA2 [nucleoplasm]

phospho-HTA2 [nucleoplasm]

Stable Identifier

R-SCE-5683942-2

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Synonyms

p-Y143-H2AFX, P04912

Locations in the PathwayBrowser

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DNA Repair (Saccharomyces cerevisiae)

- DNA Double-Strand Break Repair (Saccharomyces cerevisiae)
  - DNA Double Strand Break Response (Saccharomyces cerevisiae)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Saccharomyces cerevisiae)
      - ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Saccharomyces cerevisiae)
        
        p-Y142-H2AFX-Nucleosome [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of p-Y143-H2AFX [nucleoplasm] (Saccharomyces cerevisiae)
        
        phospho-HTA2 [nucleoplasm] (Saccharomyces cerevisiae)
      - ATM recognizes H2AFX-Nucleosomes (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Saccharomyces cerevisiae)
        
        p-Y142-H2AFX-Nucleosome [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of p-Y143-H2AFX [nucleoplasm] (Saccharomyces cerevisiae)
        
        phospho-HTA2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        p-Y142-H2AFX-Nucleosome [nucleoplasm] (Saccharomyces cerevisiae)
        
        Homologues of p-Y143-H2AFX [nucleoplasm] (Saccharomyces cerevisiae)
        
        phospho-HTA2 [nucleoplasm] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P04912

Gene Names

HTA2

Reference Genes

BioGPS Gene:852283 HTA2

ENSEMBL:YBL003C

KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YBL003C HTA2

Monarch:852283 HTA2

NCBI Gene:852283 HTA2

SGD:YBL003C

Reference Transcript

RefSeq:NM_001178243.1 HTA2

Other Identifiers

1775235_at

1777647_s_at

7358_s_at

852283

GO:0000786

GO:0000788

GO:0003674

GO:0003677

GO:0005198

GO:0005575

GO:0005634

GO:0005694

GO:0006281

GO:0006325

GO:0006333

GO:0006342

GO:0006974

GO:0008150

GO:0030527

GO:0031298

GO:0032991

GO:0046982

Participates

as a member of

Homologues of p-Y143-H2AFX [nucleoplasm] (Saccharomyces cerevisiae)

Other forms of this molecule

HTA2 [nucleoplasm]

phospho-HTA2 [nucleoplasm]

HTA2 [nucleoplasm]

Inferred From

p-Y143-H2AFX [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 143 (in Homo sapiens)

Coordinate

143

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_009552.1

PRO

P04912

PDB

4KUD, 8F0X, 4JJN, 7E9C, 7E9F, 8F1E

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02309	14	HHF2 [nucleoplasm] (R-SCE-4570518) HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-4568744) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-5423110) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-5651652) HHF2 [nucleoplasm] (R-SCE-181902)	0.839	19
UniProt:P32558	1	SPT16 [nucleoplasm] (R-SCE-112415)	0.669	43
UniProt:Q04636	1	POB3 [nucleoplasm] (R-SCE-65105)	0.669	17
UniProt:P32833 ORC2	2	yORC2 [nucleoplasm] (R-SCE-9749316) ORC2 [nucleoplasm] (R-SCE-68405)	0.564	3
UniProt:P06786	4	monoSUMO1-K-TOP2B [nucleoplasm] (R-SCE-4641297) TOP2B [nucleoplasm] (R-SCE-4641359) monoSUMO1-K-TOP2A [nucleoplasm] (R-SCE-4641367) TOP2A [nucleoplasm] (R-SCE-1362276)	0.564	8
UniProt:P54784 ORC1	6	ORC1 [nucleoplasm] (R-SCE-68522) yORC1 [nucleoplasm] (R-SCE-9749323) ORC1 [cytosol] (R-SCE-113840) phospho-p-S,T-ORC1 [nucleoplasm] (R-SCE-68943) phospho-PolyUb,p-S,T-ORC1 [nucleoplasm] (R-SCE-9032189) phospho-PolyUb,p-S,T-ORC1 [cytosol] (R-SCE-9032195)	0.527	2
UniProt:P27692	1	phospho-SPT5 [nucleoplasm] (R-SCE-3009372)	0.527	3
UniProt:Q01477	2	UBP3 [nucleoplasm] (R-SCE-3222218) UBP3 [cytosol] (R-SCE-6782974)	0.527	2

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