Reactome | RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm]

RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm]

Stable Identifier

R-SCE-5682608

Type

Complex

Species

Saccharomyces cerevisiae

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

DNA Repair (Saccharomyces cerevisiae)

- DNA Double-Strand Break Repair (Saccharomyces cerevisiae)
  - DNA Double Strand Break Response (Saccharomyces cerevisiae)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Saccharomyces cerevisiae)
      - ATM phosphorylates TP53BP1 at DNA DSBs (Saccharomyces cerevisiae)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
      - PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
      - PPP5C dephosphorylates TP53BP1 (Saccharomyces cerevisiae)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
      - RNF8 and RNF168 ubiquitinate H2AFX (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
      - RNF8 and RNF168 ubiquitinate KDM4A,B (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
      - TP53BP1 associates with H4K20Me2 at DNA DSBs (Saccharomyces cerevisiae)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
        
        RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a component of

Inferred From

RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Homo sapiens)

Cite Us!