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DMA2 [nucleoplasm]
Stable Identifier
R-SCE-5682539
Type
Protein [EntityWithAccessionedSequence]
Species
Saccharomyces cerevisiae
Compartment
nucleoplasm
Synonyms
RNF8, P53924
Locations in the PathwayBrowser
Expand all
DNA Repair (Saccharomyces cerevisiae)
DNA Double-Strand Break Repair (Saccharomyces cerevisiae)
DNA Double Strand Break Response (Saccharomyces cerevisiae)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Saccharomyces cerevisiae)
ATM phosphorylates HERC2 (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
ATM phosphorylates TP53BP1 at DNA DSBs (Saccharomyces cerevisiae)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
PPP5C dephosphorylates TP53BP1 (Saccharomyces cerevisiae)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8 and RNF168 ubiquitinate H2AFX (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8 and RNF168 ubiquitinate KDM4A,B (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8 binds phosphorylated MDC1 at DNA DSBs (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
TP53BP1 associates with H4K20Me2 at DNA DSBs (Saccharomyces cerevisiae)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+:SUMO1:p-T4827-HERC2 [nucleoplasm] (Saccharomyces cerevisiae)
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
DMA2 [nucleoplasm] (Saccharomyces cerevisiae)
External Reference Information
External Reference
UniProt:P53924
Gene Names
DMA2
Reference Genes
BioGPS Gene:855607 DMA2
ENSEMBL:YNL116W
KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YNL116W DMA2
Monarch:855607 DMA2
NCBI Gene:855607 DMA2
SGD:YNL116W
Reference Transcript
RefSeq:NM_001182954.3 DMA2
Other Identifiers
1770508_at
855607
8960_at
GO:0000132
GO:0000151
GO:0000278
GO:0000910
GO:0000921
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005737
GO:0005829
GO:0005856
GO:0005933
GO:0005934
GO:0005938
GO:0006511
GO:0007010
GO:0007049
GO:0008150
GO:0008270
GO:0016567
GO:0016740
GO:0023052
GO:0030427
GO:0031578
GO:0032153
GO:0032177
GO:0032186
GO:0033043
GO:0042787
GO:0043167
GO:0046872
GO:0048285
GO:0051301
GO:0051603
GO:0051716
GO:0051726
GO:0051865
GO:0061630
GO:0070647
GO:0070925
GO:0090337
GO:0097271
Participates
as a component of
RNF8:Zn2+ [nucleoplasm] (Saccharomyces cerevisiae)
Inferred From
RNF8 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_014283.3
IntEnz
2.3.2.27
PRO
P53924
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