Reactome | HSC82 [plasma membrane]

HSC82 [plasma membrane]

Stable Identifier

R-SCE-534996-2

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

plasma membrane

Synonyms

HSP90AA1, P15108

Locations in the PathwayBrowser

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Metabolism (Saccharomyces cerevisiae)

- Metabolism of nitric oxide: NOS3 activation and regulation (Saccharomyces cerevisiae)
  - eNOS activation (Saccharomyces cerevisiae)
    - AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)
      - eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
        
        eNOS:CaM:HSP90 [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of HSP90AA1 [plasma membrane] (Saccharomyces cerevisiae)
        
        HSC82 [plasma membrane] (Saccharomyces cerevisiae)

Signal Transduction (Saccharomyces cerevisiae)

- Signaling by Receptor Tyrosine Kinases (Saccharomyces cerevisiae)
  - Signaling by VEGF (Saccharomyces cerevisiae)
    - VEGFA-VEGFR2 Pathway (Saccharomyces cerevisiae)
      - VEGFR2 mediated vascular permeability (Saccharomyces cerevisiae)
        
        AKT1 phosphorylates eNOS (Saccharomyces cerevisiae)
        
        eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Saccharomyces cerevisiae)
        
        eNOS:CaM:HSP90 [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of HSP90AA1 [plasma membrane] (Saccharomyces cerevisiae)
        
        HSC82 [plasma membrane] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P15108

Gene Names

HSC82

Reference Genes

BioGPS Gene:855224 HSC82

ENSEMBL:YMR186W

KEGG:sce:YMR186W HSC82

Monarch:855224 HSC82

NCBI Gene:855224 HSC82

SGD:YMR186W

UCSC:P15108 HSC82

Reference Transcript

RefSeq:NM_001182692.1 HSC82

Other Identifiers

855224

GO:0000492

GO:0000723

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005618

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006457

GO:0006458

GO:0008150

GO:0009277

GO:0009408

GO:0009986

GO:0016020

GO:0016787

GO:0016887

GO:0032200

GO:0032991

GO:0034605

GO:0042026

GO:0043167

GO:0043248

GO:0048471

GO:0050821

GO:0051082

GO:0070482

GO:0140657

GO:0140662

Participates

as a member of

Homologues of HSP90AA1 [plasma membrane] (Saccharomyces cerevisiae)

Other forms of this molecule

HSC82 [secretory granule lumen]

HSC82 [ficolin-1-rich granule lumen]

HSC82 [extracellular region]

HSC82 [nucleoplasm]

HSC82 [cytosol]

Inferred From

HSP90AA1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_013911.1

ENSEMBL

YMR186W, YMR186W, YMR186W_mRNA

ZINC - Substances

HSC82_YEAST

ZINC target

P15108

PRO

P15108

ZINC - Predictions - Purchasable

HSC82_YEAST

PDB

6XLC, 6XLE, 6XLD, 6XLB, 6XLH, 6XLF, 6XLG

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15705	1	STI1 [cytosol] (R-SCE-443857)	0.813	23
UniProt:P53043	1	PPT1 [nucleoplasm] (R-SCE-5683410)	0.813	6
UniProt:P53874	1	UBP10 [cytosol] (R-SCE-6782780)	0.688	4
UniProt:P15303	4	phospho-SEC23 [cytosol] (R-SCE-5685740) SEC23 [ER to Golgi transport vesicle membrane] (R-SCE-204024) SEC23 [cytosol] (R-SCE-203972) SEC23 [endoplasmic reticulum membrane] (R-SCE-203976)	0.688	5
UniProt:P02829	11	HSP82 [cytosol] (R-SCE-192864) HSP82 [nucleoplasm] (R-SCE-5082399) HSP82 [nucleoplasm] (R-SCE-5082401) HSP82 [cytosol] (R-SCE-419617) HSP82 [plasma membrane] (R-SCE-534996) HSP82 [extracellular region] (R-SCE-3221946) HSP82 [ficolin-1-rich granule lumen] (R-SCE-6801491) HSP82 [ficolin-1-rich granule lumen] (R-SCE-6801470) HSP82 [extracellular region] (R-SCE-6806463) HSP82 [secretory granule lumen] (R-SCE-6801515) HSP82 [secretory granule lumen] (R-SCE-6801477)	0.678	46
UniProt:Q00955	5	ACC1 [cytosol] (R-SCE-2976730) ACC1 [cytosol] (R-SCE-1660609) ACC1 [mitochondrial outer membrane] (R-SCE-4167505-2) ACC1 [mitochondrial outer membrane] (R-SCE-2993858-2) phospho-ACC1 [mitochondrial outer membrane] (R-SCE-8876892-2)	0.657	4
UniProt:P0CG63 UBI4	20	UBI4 [cytosol] (R-SCE-939169) UBI4(1-76) [cytosol] (R-SCE-9033758) UBI4 [cytosol] (R-SCE-939250) UBI4 [nucleoplasm] (R-SCE-6782616) UBI4 [nucleoplasm] (R-SCE-6782530) UBI4 [nucleoplasm] (R-SCE-5683034) UBI4 [nucleoplasm] (R-SCE-939844) UBI4 [cytosol] (R-SCE-3095931) UBI4 [nucleoplasm] (R-SCE-6782647) UBI4 [nucleoplasm] (R-SCE-6782658) UBI4 [nucleoplasm] (R-SCE-6782612) UBI4 [nucleoplasm] (R-SCE-6782610) UBI4 [cytosol] (R-SCE-5689141) UBI4 [cytosol] (R-SCE-5689174) UBI4 [cytosol] (R-SCE-5689082) UBI4 [cytosol] (R-SCE-5689209) UBI4 [cytosol] (R-SCE-72476) UBI4 [endosome membrane] (R-SCE-939189) phospho-UBI4 [cytosol] (R-SCE-8852112) UBI4 [cytosol] (R-SCE-8853517)	0.609	3
UniProt:P13393 SPT15	2	SPT15 [nucleoplasm] (R-SCE-83718) TATA-box factor [nucleoplasm] (R-SCE-111843)	0.589	2
UniProt:Q08446	1	SGT1 [cytosol] (R-SCE-874107)	0.589	3
UniProt:Q02804 ARL3	4	AcM-ARL3 [cytosol] (R-SCE-6813860) ARL3 [cytosol] (R-SCE-6813851) ARL3 [cytosol] (R-SCE-6813853) ARL3 [trans-Golgi network membrane] (R-SCE-6813857)	0.564	2
UniProt:P38123	1	SWD3 [nucleoplasm] (R-SCE-1629838)	0.564	2
UniProt:P06778	3	RAD52 [nucleoplasm] (R-SCE-4568909) RAD52 [nucleoplasm] (R-SCE-62639) phospho-RAD52 [nucleoplasm] (R-SCE-5686588)	0.564	2
UniProt:P10592	20	SSA2 [cytosol] (R-SCE-264476) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801512-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801496-3) SSA2 [ficolin-1-rich granule lumen] (R-SCE-6801494) SSA2 [extracellular region] (R-SCE-6805872-3) SSA2 [extracellular region] (R-SCE-6806500-3) SSA2 [extracellular region] (R-SCE-6805936) SSA2 [secretory granule lumen] (R-SCE-6801530) SSA2 [secretory granule lumen] (R-SCE-6801472-3) SSA2 [cytosol] (R-SCE-3371410-3) SSA2 [cytosol] (R-SCE-3371408-3) SSA2 [cytosol] (R-SCE-6792602-3) SSA2 [nucleoplasm] (R-SCE-5082380) SSA2 [nucleoplasm] (R-SCE-6792605-3) SSA2 [nucleoplasm] (R-SCE-912480-3) SSA2 [nucleoplasm] (R-SCE-5082367-3) SSA2 [nucleoplasm] (R-SCE-5252082-3) SSA2 [nucleoplasm] (R-SCE-5252088-3) SSA2 [nucleoplasm] (R-SCE-5252009-3) SSA2 [cytosol] (R-SCE-5251948-3)	0.527	3
UniProt:P25454	2	RAD51 [nucleoplasm] (R-SCE-62637) phospho-RAD51 [nucleoplasm] (R-SCE-5685231)	0.527	2
UniProt:Q03497	10	STE20 [plasma membrane] (R-SCE-211555-2) STE20 [cytosol] (R-SCE-428459-2) STE20 [cytosol] (R-SCE-428461-2) STE20 [cytosol] (R-SCE-428454-2) phospho-STE20 [cytosol] (R-SCE-5357471-2) STE20 [cytosol] (R-SCE-428457-2) STE20 [cytosol] (R-SCE-162629) STE20 [cytosol] (R-SCE-211604-2) phospho-STE20 [cytosol] (R-SCE-399819) phospho-STE20 [cytosol] (R-SCE-399824-2)	0.527	2
UniProt:P25491	3	YDJ1 [cytosol] (R-SCE-9857072) YDJ1 [cytosol] (R-SCE-3371578) YDJ1 [cytosol] (R-SCE-3371555)	0.527	2

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