MRS3,4 Transports Iron Across the Mitochondrial Inner Membrane

Stable Identifier
R-SCE-2466303
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MRS3,4 Transports Iron Across the Mitochondrial Inner Membrane
MRS3/4 transports ferrous iron across the mitochondrial inner membrane (Foury et al. 2002, Muhlenhoff et al. 2003).
Literature References
PubMed ID Title Journal Year
12006577 Deletion of the mitochondrial carrier genes MRS3 and MRS4 suppresses mitochondrial iron accumulation in a yeast frataxin-deficient strain

Foury, F, Roganti, T

J. Biol. Chem. 2002
12902335 A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions

Mühlenhoff, U, Stadler, JA, Richhardt, N, Seubert, A, Eickhorst, T, Schweyen, RJ, Lill, R, Wiesenberger, G

J. Biol. Chem. 2003
Participants
Input
Output
Catalyst Activity

ferrous iron transmembrane transporter activity of MRS3,4 [mitochondrial inner membrane]

Physical Entity
MRS3,4 [mitochondrial inner membrane] (Saccharomyces cerevisiae)
Activity
ferrous iron transmembrane transporter activity (GO:0015093)
Orthologous Events
Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix (Homo sapiens)
Authored
Lill, R  (2012-09-24)
May, B  (2012-09-06)
Reviewed
Rouault, TA  (2012-10-12)
Tong, WH  (2012-10-12)
Created
May, B  (2012-09-06)
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