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APM4 [cytosol]
Stable Identifier
R-SCE-182227
Type
Protein [EntityWithAccessionedSequence]
Species
Saccharomyces cerevisiae
Compartment
cytosol
Synonyms
AP2M1, Q99186
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Saccharomyces cerevisiae)
Membrane Trafficking (Saccharomyces cerevisiae)
Clathrin-mediated endocytosis (Saccharomyces cerevisiae)
AAK1 phosphorylates AP-2 mu subunit at T156 (Saccharomyces cerevisiae)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
BAR domain proteins recruit dynamin (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
Cargo recognition for clathrin-mediated endocytosis (Saccharomyces cerevisiae)
AP-2 directly binds some endocytic cargo (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
AP-2:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
AP2:chlorpromazine [cytosol] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
AP2 binds chlorpromazine (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
AP2:chlorpromazine [cytosol] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
Clathrin recruits auxilins to the clathrin-coated vesicle (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Saccharomyces cerevisiae)
AP-2:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
Endophilins recruit synaptojanins to the clathrin-coated pit (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
FCHo proteins bind nascent clathrin-coated pit (Saccharomyces cerevisiae)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
RAB5 and GAPVD1 bind AP-2 (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Saccharomyces cerevisiae)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Saccharomyces cerevisiae)
AP-2:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Saccharomyces cerevisiae)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2:cargo [plasma membrane] (Saccharomyces cerevisiae)
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
APM4 [cytosol] (Saccharomyces cerevisiae)
External Reference Information
External Reference
UniProt:Q99186
Gene Names
APM4
Reference Genes
BioGPS Gene:854092 APM4
ENSEMBL:YOL062C
KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YOL062C APM4
Monarch:854092 APM4
NCBI Gene:854092 APM4
SGD:YOL062C
Reference Transcript
RefSeq:NM_001183317.1 APM4
Other Identifiers
1779639_at
854092
8635_at
GO:0005575
GO:0005737
GO:0005886
GO:0006886
GO:0006897
GO:0008150
GO:0012505
GO:0015031
GO:0016020
GO:0016192
GO:0030122
GO:0030131
GO:0031410
Participates
as a component of
AP-2 Complex [cytosol] (Saccharomyces cerevisiae)
Other forms of this molecule
APM4 [cytosol]
APM4 [cytosol]
APM4 [cytosol]
APM4 [cytosol]
phospho-APM4 [cytosol]
APM4 [lysosomal membrane]
APM4 [endolysosome membrane]
APM4 [plasma membrane]
Inferred From
AP2M1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_014579.1
PRO
Q99186
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