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SKP1 [cytosol]
Stable Identifier
R-SCE-174150
Type
Protein [EntityWithAccessionedSequence]
Species
Saccharomyces cerevisiae
Compartment
cytosol
Synonyms
SKP1, P52286
Locations in the PathwayBrowser
Expand all
Cell Cycle (Saccharomyces cerevisiae)
Cell Cycle, Mitotic (Saccharomyces cerevisiae)
Mitotic G2-G2/M phases (Saccharomyces cerevisiae)
G2/M Transition (Saccharomyces cerevisiae)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Saccharomyces cerevisiae)
Formation of the SCF-FBXL7 complex (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Saccharomyces cerevisiae)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Saccharomyces cerevisiae)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
SCF-FBXL18 ubiquitinates FBXL7 (Saccharomyces cerevisiae)
SKP1:CUL1:RBX1:FBXL18 [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
SCF-FBXL7 ubiquitinates AURKA (Saccharomyces cerevisiae)
SCF-FBXL7:AURKA [cytosol] (Saccharomyces cerevisiae)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
SCF-FBXL7:PolyUb-AURKA [cytosol] (Saccharomyces cerevisiae)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
SCF:FBXL7 binds AURKA (Saccharomyces cerevisiae)
SCF-FBXL7:AURKA [cytosol] (Saccharomyces cerevisiae)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
Immune System (Saccharomyces cerevisiae)
Adaptive Immune System (Saccharomyces cerevisiae)
Class I MHC mediated antigen processing & presentation (Saccharomyces cerevisiae)
Antigen processing: Ubiquitination & Proteasome degradation (Saccharomyces cerevisiae)
Interaction of E3 with substrate and E2-Ub complex (Saccharomyces cerevisiae)
Ag-substrate:E3:E2:Ub [cytosol] (Saccharomyces cerevisiae)
E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
Polyubiquitination of substrate (Saccharomyces cerevisiae)
E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
E3:K48-polyubiquitinated substrate [cytosol] (Saccharomyces cerevisiae)
E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
E3:Ub:substrate [cytosol] (Saccharomyces cerevisiae)
E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
Release of E3 from polyubiquitinated substrate (Saccharomyces cerevisiae)
E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
E3:K48-polyubiquitinated substrate [cytosol] (Saccharomyces cerevisiae)
E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
Transfer of Ub from E2 to substrate and release of E2 (Saccharomyces cerevisiae)
Ag-substrate:E3:E2:Ub [cytosol] (Saccharomyces cerevisiae)
E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
E3:Ub:substrate [cytosol] (Saccharomyces cerevisiae)
E3 ligases in proteasomal degradation [cytosol] (Saccharomyces cerevisiae)
SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
Transport of small molecules (Saccharomyces cerevisiae)
Iron uptake and transport (Saccharomyces cerevisiae)
CUL1, SKP1, FBXL5 bind (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
SKP1:CUL1:FBXL5 [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5) (Saccharomyces cerevisiae)
SKP1:CUL1:FBXL5 [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
SKP1:FBXL5:CUL1:NEDD8 [cytosol] (Saccharomyces cerevisiae)
SKP1:CUL1:FBXL5 [cytosol] (Saccharomyces cerevisiae)
SKP1 [cytosol] (Saccharomyces cerevisiae)
External Reference Information
External Reference
UniProt:P52286
Gene Names
SKP1
Reference Genes
BioGPS Gene:851928 SKP1
ENSEMBL:YDR328C
KEGG Gene (Saccharomyces cerevisiae (strain RM11-1a)):YDR328C SKP1
Monarch:851928 SKP1
NCBI Gene:851928 SKP1
SGD:YDR328C
Reference Transcript
RefSeq:NM_001180636.3 SKP1
Other Identifiers
1778975_at
6160_at
851928
GO:0000082
GO:0000086
GO:0000278
GO:0000409
GO:0000775
GO:0000776
GO:0000777
GO:0000781
GO:0000921
GO:0002181
GO:0003674
GO:0003677
GO:0003688
GO:0004842
GO:0005515
GO:0005575
GO:0005634
GO:0005694
GO:0005737
GO:0006325
GO:0006417
GO:0006511
GO:0006873
GO:0006974
GO:0007005
GO:0007010
GO:0007035
GO:0007096
GO:0007346
GO:0008053
GO:0008150
GO:0008643
GO:0010458
GO:0010828
GO:0012505
GO:0016567
GO:0016740
GO:0019005
GO:0019222
GO:0023052
GO:0030466
GO:0031146
GO:0031335
GO:0031509
GO:0031518
GO:0031573
GO:0032200
GO:0042221
GO:0042787
GO:0043254
GO:0043291
GO:0043623
GO:0045116
GO:0048284
GO:0048285
GO:0051049
GO:0051382
GO:0051603
GO:0051726
GO:0055085
GO:0061630
GO:0065003
GO:0070072
GO:0070647
GO:0070925
GO:0071406
GO:0097602
GO:2000766
Participates
as an input of
Formation of the SCF-FBXL7 complex (Saccharomyces cerevisiae)
CUL1, SKP1, FBXL5 bind (Saccharomyces cerevisiae)
as a component of
SKP1:CUL1:RBX1:FBXL7 [cytosol] (Saccharomyces cerevisiae)
SKP1:CUL1:RBX1:FBXL18 [cytosol] (Saccharomyces cerevisiae)
SKP1:CUL1:FBXL5 [cytosol] (Saccharomyces cerevisiae)
BTRC:CUL1:RBX1:SKP1 [cytosol] (Saccharomyces cerevisiae)
SCF E3 ubiquitin ligase [cytosol] (Saccharomyces cerevisiae)
CUL1:FBXW11:SKP1 [cytosol] (Saccharomyces cerevisiae)
Other forms of this molecule
SKP1 [nucleoplasm]
Inferred From
SKP1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_010615.3
OpenTargets
ENSG00000113558
PRO
P52286
PDB
6GYU
,
5AN3
,
7K79
,
1NEX
,
3MKS
,
8OW1
,
6GSA
,
8GRE
,
7PMN
,
6GYP
,
6F07
,
7PMK
,
6FE8
,
3V7D
,
6GYS
,
8GRF
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07834 CDC4
0.953
14
UniProt:P39014 MET30
0.952
15
UniProt:Q12018
3
CDC53 [cytosol]
(R-SCE-180528)
CDC53 [nucleoplasm]
(R-SCE-187551)
CDC53 [cytosol]
(R-SCE-174230)
0.93
30
UniProt:P24814 GRR1
0.925
9
UniProt:P35203 CBF3C
0.885
8
UniProt:Q04847 ROY1
0.854
7
UniProt:Q04511
1
UFO1 [cytosol]
(R-SCE-391305)
0.836
7
UniProt:P42843 SKP2
0.836
6
UniProt:Q08446
1
SGT1 [cytosol]
(R-SCE-874107)
0.833
8
UniProt:Q12347
1
HRT3 [cytosol]
(R-SCE-8862608)
0.796
5
UniProt:Q05930 MDM30
0.791
5
UniProt:P38352 SAF1
0.748
5
UniProt:Q06479
5
PolyUb-K109-FBXL7 [cytosol]
(R-SCE-8854053)
FBXL5 [cytosol]
(R-SCE-391295)
FBXL13 [cytosol]
(R-SCE-8862616)
FBXL7 [cytosol]
(R-SCE-8854032)
FBXL16 [cytosol]
(R-SCE-8862609)
0.738
4
UniProt:Q05947 UCC1
0.737
4
UniProt:P47104 RAV1
0.723
6
UniProt:P47005 DAS1
0.723
4
UniProt:P39531 RCY1
0.723
4
UniProt:Q08496 DIA2
0.723
4
UniProt:P32504 CBF3A
0.71
4
UniProt:P14682
8
CDC34 [cytosol]
(R-SCE-8864180)
CDC34 [cytosol]
(R-SCE-8864149)
CDC34 [cytosol]
(R-SCE-8864170)
CDC34 [nucleoplasm]
(R-SCE-8864204)
CDC34 [nucleoplasm]
(R-SCE-8852125)
CDC34 [cytosol]
(R-SCE-947621)
CDC34 [cytosol]
(R-SCE-947627)
CDC34 [cytosol]
(R-SCE-947630)
0.669
14
UniProt:Q12348 CSN10
0.669
4
UniProt:Q06150 BOP2
0.659
3
UniProt:Q03956 RAV2
0.643
3
UniProt:Q08273
3
RBX1 [nucleoplasm]
(R-SCE-1234142)
RNF7 (RBX2) [cytosol]
(R-SCE-8863132)
RBX1 [cytosol]
(R-SCE-180582)
0.643
17
UniProt:P40969 CBF3B
0.643
3
UniProt:Q03899 YD131
0.642
4
UniProt:Q06640
6
PolyUb-K109-FBXL7 [cytosol]
(R-SCE-8854053-2)
FBXL5 [cytosol]
(R-SCE-391295-2)
FBXL20 [cytosol]
(R-SCE-8862591)
FBXL13 [cytosol]
(R-SCE-8862616-2)
FBXL7 [cytosol]
(R-SCE-8854032-2)
FBXL16 [cytosol]
(R-SCE-8862609-2)
0.642
3
UniProt:Q9NVF7 FBX28
0.556
3
UniProt:Q9NXK8 FBXL12
1
FBXL12 [cytosol]
(R-HSA-8862611)
0.556
3
UniProt:Q03919
7
RUB1 [nucleoplasm]
(R-SCE-8952504)
RUB1 [cytosol]
(R-SCE-8951739)
RUB1 [cytosol]
(R-SCE-6782654)
RUB1 [cytosol]
(R-SCE-5690794)
RUB1 [cytosol]
(R-SCE-8951647)
RUB1 [cytosol]
(R-SCE-416969)
RUB1 [cytosol]
(R-SCE-4419895)
0.547
2
UniProt:P09232
3
PRB1 [endolysosome membrane]
(R-SCE-6784823)
PRB1 [lysosomal membrane]
(R-SCE-8855128)
PRB1 [extracellular region]
(R-SCE-6784727)
0.527
2
UniProt:P36018
18
RAB5C [Golgi membrane]
(R-SCE-434334)
RAB5C [cytoplasmic vesicle membrane]
(R-SCE-434198)
GGC-RAB5A [early endosome membrane]
(R-SCE-8875323)
GGC-RAB5B [early endosome membrane]
(R-SCE-8875327)
GGC-RAB5C [early endosome membrane]
(R-SCE-8875331)
GGC-RAB5A [cytosol]
(R-SCE-8870432)
GGC-RAB5B [cytosol]
(R-SCE-8870434)
GGC-RAB17 [cytosol]
(R-SCE-8873764)
GGC-RAB5C [cytosol]
(R-SCE-8870436)
RAB17 [cytosol]
(R-SCE-8873703)
RAB5B [cytosol]
(R-SCE-8870412)
RAB5C [cytosol]
(R-SCE-8870413)
RAB5A [endosome membrane]
(R-SCE-452257)
RAB5A [cytosol]
(R-SCE-2201187)
RAB5C [plasma membrane]
(R-SCE-6806265)
RAB5C [azurophil granule membrane]
(R-SCE-6799338)
RAB5B [plasma membrane]
(R-SCE-6804984)
RAB5B [secretory granule membrane]
(R-SCE-6804966)
0.527
2
UniProt:Q04922 MFB1
0.527
2
UniProt:P47822 MED21
0.508
2
UniProt:P32324 EFT1
11
Me3K525-EEF2 [cytosol]
(R-SCE-8932237)
diphthine EFT1 [cytosol]
(R-SCE-5367015)
Me-diphthine EFT1 [cytosol]
(R-SCE-5367013)
diphthine EEF2 [cytosol]
(R-SCE-5358501)
nascent EEF2 [cytosol]
(R-SCE-5358472)
Me-diphthine EEF2 [cytosol]
(R-SCE-5367025)
aminocarboxypropyl EEF2 [cytosol]
(R-SCE-5358478)
EEF2 [cytosol]
(R-SCE-156901)
EEF2 [secretory granule lumen]
(R-SCE-6801504)
EEF2 [ficolin-1-rich granule lumen]
(R-SCE-6801513)
EEF2 [extracellular region]
(R-SCE-6806499)
0.499
2
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