Reactome | GPA1 [plasma membrane]

GPA1 [plasma membrane]

Stable Identifier

R-SCE-167453

Type

Protein [EntityWithAccessionedSequence]

Species

Saccharomyces cerevisiae

Compartment

plasma membrane

Synonyms

GNA14, P08539

Locations in the PathwayBrowser

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Hemostasis (Saccharomyces cerevisiae)

- Platelet activation, signaling and aggregation (Saccharomyces cerevisiae)
  - Signal amplification (Saccharomyces cerevisiae)
    - ADP signalling through P2Y purinoceptor 1 (Saccharomyces cerevisiae)
      - P2Y purinoceptor 1 activates MAP kinase p38 alpha (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of GNA14 [plasma membrane] (Saccharomyces cerevisiae)
        
        GPA1 [plasma membrane] (Saccharomyces cerevisiae)

Signal Transduction (Saccharomyces cerevisiae)

- Signaling by GPCR (Saccharomyces cerevisiae)
  - GPCR downstream signalling (Saccharomyces cerevisiae)
    - G alpha (q) signalling events (Saccharomyces cerevisiae)
      - Active G alpha (q) binds RGS proteins (Saccharomyces cerevisiae)
        
        G alpha (q):GTP:RGS [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of GNA14 [plasma membrane] (Saccharomyces cerevisiae)
        
        GPA1 [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of GNA14 [plasma membrane] (Saccharomyces cerevisiae)
        
        GPA1 [plasma membrane] (Saccharomyces cerevisiae)
      - G alpha (q) auto-inactivates by hydrolysing GTP to GDP (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of GNA14 [plasma membrane] (Saccharomyces cerevisiae)
        
        GPA1 [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of GNA14 [plasma membrane] (Saccharomyces cerevisiae)
        
        GPA1 [plasma membrane] (Saccharomyces cerevisiae)
      - G alpha (q) in G (q):RGS complex is inactivated (Saccharomyces cerevisiae)
        
        G alpha (q):GDP:RGS [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of GNA14 [plasma membrane] (Saccharomyces cerevisiae)
        
        GPA1 [plasma membrane] (Saccharomyces cerevisiae)
        
        G alpha (q):GTP:RGS [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of GNA14 [plasma membrane] (Saccharomyces cerevisiae)
        
        GPA1 [plasma membrane] (Saccharomyces cerevisiae)
      - G alpha (q):RGS dissociates to inactive G alpha (q) (Saccharomyces cerevisiae)
        
        G alpha (q):GDP:RGS [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of GNA14 [plasma membrane] (Saccharomyces cerevisiae)
        
        GPA1 [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11):GDP [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of GNA14 [plasma membrane] (Saccharomyces cerevisiae)
        
        GPA1 [plasma membrane] (Saccharomyces cerevisiae)
      - PLC-beta hydrolyses PIP2 to DAG and IP3 (Saccharomyces cerevisiae)
        
        PLC beta:G alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of GNA14 [plasma membrane] (Saccharomyces cerevisiae)
        
        GPA1 [plasma membrane] (Saccharomyces cerevisiae)
        
        PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Saccharomyces cerevisiae)
        
        PLC beta:G alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of GNA14 [plasma membrane] (Saccharomyces cerevisiae)
        
        GPA1 [plasma membrane] (Saccharomyces cerevisiae)
        
        PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] (Saccharomyces cerevisiae)
        
        PLC beta:G alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11): GTP [plasma membrane] (Saccharomyces cerevisiae)
        
        G-protein alpha (q/11) [plasma membrane] (Saccharomyces cerevisiae)
        
        Homologues of GNA14 [plasma membrane] (Saccharomyces cerevisiae)
        
        GPA1 [plasma membrane] (Saccharomyces cerevisiae)

External Reference Information

External Reference

UniProt:P08539

Gene Names

GPA1

Reference Genes

BioGPS Gene:856394 GPA1

ENSEMBL:YHR005C

KEGG Gene (Saccharomyces cerevisiae):YHR005C GPA1

Monarch:856394 GPA1

NCBI Gene:856394 GPA1

SGD:YHR005C

Reference Transcript

RefSeq:NM_001179135.1 GPA1

Other Identifiers

1769776_at

4522_at

856394

GO:0000742

GO:0000743

GO:0000746

GO:0000750

GO:0000754

GO:0001664

GO:0003674

GO:0003924

GO:0004871

GO:0005525

GO:0005575

GO:0005737

GO:0005768

GO:0005834

GO:0005886

GO:0006997

GO:0007165

GO:0007186

GO:0007188

GO:0008150

GO:0010008

GO:0012505

GO:0015031

GO:0016020

GO:0016787

GO:0019001

GO:0023052

GO:0031410

GO:0031683

GO:0042221

GO:0043167

GO:0046872

GO:0048017

GO:0048284

GO:0051049

GO:0051169

GO:0071701

Participant Of

hasMember

Homologues of GNA14 [plasma membrane]

Other forms of this molecule

GPA1 [plasma membrane]

Inferred From

GNA14 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_011868.1

PRO

P08539

PDB

1SCG

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18851	4	STE4 [cytosol] (R-SCE-6814200) STE4 [plasma membrane] (R-SCE-164347) STE4 [cytosol] (R-SCE-6814203) STE4 [cytosol] (R-SCE-6814204)	0.9	8
UniProt:P11972	12	SST2 [plasma membrane] (R-SCE-939799) SST2 [plasma membrane] (R-SCE-939787) SST2 [plasma membrane] (R-SCE-8849407) SST2 [plasma membrane] (R-SCE-939769) SST2 [plasma membrane] (R-SCE-939775) SST2 [plasma membrane] (R-SCE-939776) SST2 [plasma membrane] (R-SCE-8849408) SST2 [plasma membrane] (R-SCE-8849226) SST2 [plasma membrane] (R-SCE-921136) SST2 [plasma membrane] (R-SCE-939779) SST2 [plasma membrane] (R-SCE-921135) SST2 [plasma membrane] (R-SCE-921129)	0.641	3
UniProt:P22543	2	VPS34 [cytosol] (R-SCE-188011) VPS34 [phagocytic vesicle membrane] (R-SCE-6798182)	0.556	3
UniProt:P16892	11	FUS3 [extracellular region] (R-SCE-6806250) FUS3 [azurophil granule lumen] (R-SCE-6799225) FUS3 [ficolin-1-rich granule lumen] (R-SCE-6800964) FUS3 [nucleoplasm] (R-SCE-199960) FUS3 [nucleoplasm] (R-SCE-73724-2) FUS3 [cytosol] (R-SCE-59284-2) phospho-FUS3 [cytosol] (R-SCE-109842-2) phospho-FUS3 [cytosol] (R-SCE-109853) FUS3 [cytosol] (R-SCE-59282) phospho-FUS3 [nucleoplasm] (R-SCE-112359-2) phospho-FUS3 [nucleoplasm] (R-SCE-112354)	0.544	2
UniProt:P22219	2	VPS15 [cytosol] (R-SCE-188010) VPS15 [phagocytic vesicle membrane] (R-SCE-6798171)	0.524	2

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