Precursor proteins enter TIM23 PAM complex

Stable Identifier
R-SCE-1268014
Type
Reaction [binding]
Species
Saccharomyces cerevisiae
Compartment
General
SVG |   | PPTX  | SBGN
Precursor proteins enter TIM23 PAM complex

The TIM23 Complex resides in the inner membrane of the mitochondrion and transfers precursor proteins to the matrix. The TIM23 complex appears to adopt different configurations (and perhaps different subunit compositions) depending on whether the substrate is destined for the inner membrane or the matrix. Here we refer to the TIM23 PAM complex as the configuration that delivers inner membrane proteins. The PAM17 subunit is required for this activity. The N-terminal presequence of precursors first interacts with TIM50 and TIM23 (Mokranjac et al. 2003, Martinez-Caballero et al. 2007, Tamura et al. 2009). The TIM17 and TIM23 subunits form a channel and are required to initiate translocation of precursors (Milislav et al. 2001).
Substrates of TIM23 PAM include Hsp60 (Gallas et al. 2006) and Yfh1 (Voisine et al. 2000).

Literature References
PubMed ID Title Journal Year
15797382 Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17

Chacinska, A, Lind, M, Frazier, AE, Dudek, J, Meisinger, C, Geissler, A, Sickmann, A, Meyer, HE, Truscott, KN, Guiard, B, Pfanner, N, Rehling, P

Cell 2005
19884344 Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting

Chacinska, A, van der Laan, M, Mehnert, CS, Guiard, B, Mick, DU, Hutu, DP, Truscott, KN, Wiedemann, N, Meisinger, C, Pfanner, N, Rehling, P

Mol Cell Biol 2010
18418384 Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria

Popov-Celeketi?, D, Mapa, K, Neupert, W, Mokranjac, D

EMBO J 2008
12574118 Tim50, a novel component of the TIM23 preprotein translocase of mitochondria

Mokranjac, D, Paschen, SA, Kozany, C, Prokisch, H, Hoppins, SC, Nargang, FE, Neupert, W, Hell, K

EMBO J 2003
18400944 Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase

Hutu, DP, Guiard, B, Chacinska, A, Becker, D, Pfanner, N, Rehling, P, van der Laan, M

Mol Biol Cell 2008
10779357 Role of the mitochondrial Hsp70s, Ssc1 and Ssq1, in the maturation of Yfh1

Voisine, C, Schilke, B, Ohlson, M, Beinert, H, Marszalek, J, Craig, EA

Mol Cell Biol 2000
11344168 Modular structure of the TIM23 preprotein translocase of mitochondria

Milisav, I, Moro, F, Neupert, W, Brunner, M

J Biol Chem 2001
16790493 Characterization of Mmp37p, a Saccharomyces cerevisiae mitochondrial matrix protein with a role in mitochondrial protein import

Gallas, MR, Dienhart, MK, Stuart, RA, Long, RM

Mol Biol Cell 2006
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