TIM8:TIM13 chaperones hydrophobic proteins

Stable Identifier
R-SCE-1252262
Type
Reaction [binding]
Species
Saccharomyces cerevisiae
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
TIM8:TIM13 chaperones hydrophobic proteins
The TIM8:TIM13 complex chaperones hydrophobic membrane proteins in the intermembrane space until their insertion into the inner or outer membrane (Leuenberger et al. 1999, Davis et al. 2000, Paschen et al. 2000, Curran et al. 2002, Wiedemann et al. 2004, Davis et al. 2007, Beverly et al. 2008, Hasson et al. 2010). Substrates of the TIM8:TIM13 complex include TIM23 (Leuenberger et al. 1999, Davis et al. 2000, Paschen et al. 2000, Curran et al. 2002, Davis et al. 2007, Beverly et al. 2008, Hasson et al. 2010) and TOM40 (Wiedemann et al. 2004).
Literature References
PubMed ID Title Journal Year
10995434 Two intermembrane space TIM complexes interact with different domains of Tim23p during its import into mitochondria

Holder, J, Davis, AJ, Jensen, RE, Sepuri, NB, Johnson, AE

J Cell Biol 2000
20457929 Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation

Dabir, DV, Hasson, SA, Walker, SS, Koehler, CM, Glavin, JD, Damoiseaux, R

Proc Natl Acad Sci U S A 2010
12221072 The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins

Curran, SP, Leuenberger, D, Schmidt, E, Koehler, CM

J Cell Biol 2002
14978039 Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway

Pfanner, N, Wiedemann, N, Guiard, B, Pfannschmidt, S, Meisinger, C, Truscott, KN

J Biol Chem 2004
17122363 The Tim9p/10p and Tim8p/13p complexes bind to specific sites on Tim23p during mitochondrial protein import

Davis, AJ, Jensen, RE, Johnson, AE, Alder, NN

Mol Biol Cell 2007
10469659 Different import pathways through the mitochondrial intermembrane space for inner membrane proteins

Schatz, G, Leuenberger, D, Bally, NA, Koehler, CM

EMBO J 1999
18706423 The Tim8-Tim13 complex has multiple substrate binding sites and binds cooperatively to Tim23

Beverly, KN, Schmid, E, Sawaya, MR, Koehler, CM

J Mol Biol 2008
11101512 The role of the TIM8-13 complex in the import of Tim23 into mitochondria

Neupert, W, Paschen, SA, Brunner, M, K√°ldi, K, Rothbauer, U, Bauer, MF

EMBO J 2000
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