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Plcg2 [cytosol]
Stable Identifier
R-RNO-984806
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
PLCG2, P24135
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
BTK binds BTK inhibitors (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
BTK:BTK inhibitors [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-DAPP1 (p-BAM32) binds PLCG2 (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
Dectin-2 family (Rattus norvegicus)
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
DAP12 interactions (Rattus norvegicus)
DAP12 signaling (Rattus norvegicus)
Activation of RAC1 by VAV2/3 (Rattus norvegicus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Phosphorylation of BTK by p-SYK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-SYK/p-BTK [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated Ca+2 mobilization (Rattus norvegicus)
Autophosphorylation of BTK/ITK (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
FCERI mediated MAPK activation (Rattus norvegicus)
Activation of RAC1 by VAV (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Autophosphorylation of PAK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Phosphorylation and activation of VAV (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Recruitment of PAK to the membrane by binding active RAC1 (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Recruitment of VAV to p-SLP-76 (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Role of phospholipids in phagocytosis (Rattus norvegicus)
Phosphorylation and activation of PLCG (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Recruitment of PLCgamma to membrane (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Rattus norvegicus)
PLC gamma1,2 [cytosol] (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
Endocytosis of TLR4:LY96:LPS:CD14 (Rattus norvegicus)
Plcg2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P24135 Plcg2
Gene Names
Plcg2
Chain
chain:1-1265
Reference Genes
BioGPS Gene:29337 Plcg2
KEGG Gene (Rattus norvegicus):29337 Plcg2
Monarch:29337 Plcg2
NCBI Gene:29337 Plcg2
UCSC:P24135 Plcg2
Reference Transcript
RefSeq:NM_017168.1 Plcg2
Participates
as a component of
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Rattus norvegicus)
p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
PLCG2:PIP3 [plasma membrane] (Rattus norvegicus)
as an input of
p-DAPP1 (p-BAM32) binds PLCG2 (Rattus norvegicus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)
as a member of
PLC gamma1,2 [cytosol] (Rattus norvegicus)
This entity regulates
Positively
Endocytosis of TLR4:LY96:LPS:CD14
(Rattus norvegicus)
Other forms of this molecule
phospho-Plcg2 [cytosol]
phospho-Plcg2 [plasma membrane]
p-Y753,Y759,Y1197,Y1217-Plcg2 [plasma membrane]
phospho-Plcg2 [plasma membrane]
Plcg2 [plasma membrane]
phospho-Plcg2 [plasma membrane]
Inferred From
PLCG2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_058864.1
PRO
P24135
RGD
3348
PDB
2EOB
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