Reactome | SPSB1 [cytosol]

SPSB1 [cytosol]

Stable Identifier

R-RNO-976024

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

B0BMX8

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        SPSB1 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        SPSB1 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        SPSB1 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        SPSB1 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        SPSB1 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        SPSB1 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        SPSB1 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        SPSB1 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        SPSB1 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL5-box protein [cytosol] (Rattus norvegicus)
        
        SPSB1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:B0BMX8

Reference Genes

BioGPS Gene:313722

ENSEMBL:ENSRNOG00000017212

ENSEMBL:ENSRNOG00000017212.8

KEGG Gene (Rattus norvegicus):313722

Monarch:313722

NCBI Gene:313722

Reference Transcript

Other Identifiers

10881820

1373554_at

1379611_at

1393805_at

17812867

313722

5752005

5972112

6067987

6178574

A_42_P754784

A_43_P16847

GE1281701

GE18019

GO:0005515

ILMN_1367615

PH_rn_0007558

rc_AA955162_at

rc_AA963201_at

Participates

as a member of

Inferred From

SPSB1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_008762481.1, XP_008762479.1, XP_008762480.1, XP_006239524.1, XP_017448919.1, NP_001101464.1

Ensembl

ENSRNOP00000074486, ENSRNOG00000017212, ENSRNOT00000085251

RGD

1309319

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