Streptozocin (streptozotocin) produces 7-methylguanine in dsDNA

Stable Identifier
R-RNO-9730905
Type
Reaction [omitted]
Species
Rattus norvegicus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Streptozocin (streptozotocin) produces 7-methylguanine in dsDNA
Experiments in rats have shown that the monofunctional alkylating chemotherapeutic drug streptozocin (streptozotocin) produces N7-methylguanine adducts in double-stranded DNA (7meG-dsDNA) (Bennett and Pegg 1981).
Literature References
PubMed ID Title Journal Year
6454479 Alkylation of DNA in rat tissues following administration of streptozotocin

Bennett, RA, Pegg, AE

Cancer Res 1981
Participants
Input
Output
Orthologous Events
Monofunctional chemotherapeutic alkylating drugs produce 7-methylguanine in dsDNA (Homo sapiens)
Authored
Orlic-Milacic, M  (2021-05-11)
Reviewed
Kadambat Nair, S  (2021-07-28)
Created
Orlic-Milacic, M  (2021-05-11)
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