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phospho-p-Y-SYK [cytosol]
Stable Identifier
R-RNO-9705732
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Q64725
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by CSF3 (G-CSF) (Rattus norvegicus)
Inactivation of CSF3 (G-CSF) signaling (Rattus norvegicus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Rattus norvegicus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
phospho-p-Y-SYK [cytosol] (Rattus norvegicus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Rattus norvegicus)
phospho-p-Y-SYK [cytosol] (Rattus norvegicus)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Rattus norvegicus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
phospho-p-Y-SYK [cytosol] (Rattus norvegicus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Rattus norvegicus)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
phospho-p-Y-SYK [cytosol] (Rattus norvegicus)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Rattus norvegicus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Rattus norvegicus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Rattus norvegicus)
phospho-p-Y-SYK [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q64725 Syk
Gene Names
Syk
Chain
chain:1-629
Reference Genes
BioGPS Gene:25155 Syk
KEGG:rno:25155 Syk
Monarch:25155 Syk
NCBI Gene:25155 Syk
UCSC:Q64725 Syk
Reference Transcript
RefSeq:NM_012758.1 Syk
Participates
as a component of
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Rattus norvegicus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Rattus norvegicus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
phospho-p-Y-SYK [plasma membrane]
p-317Y,519Y,520Y-Syk [cytosol]
Syk [cytosol]
phospho-p-6Y-SYK [cytosol]
phospho-p-Y348-SYK [cytosol]
SYK [cytosol]
Inferred From
p-Y-SYK [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_036890.1
ZINC - Investigational
KSYK_RAT
ZINC - Metabolites
KSYK_RAT
ZINC - World Drugs
KSYK_RAT
ZINC - Substances
KSYK_RAT
ZINC - Biogenic
KSYK_RAT
ZINC target
Q64725
PRO
Q64725
RGD
3796
ZINC - Predictions - Purchasable
KSYK_RAT
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