Chrna9:Chrna10 binds acetylcholine (AcCho)

Stable Identifier
R-RNO-9667857
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Chrna9:Chrna10 binds acetylcholine (AcCho)
Chrna9:Chrna10, an unusual nicotinic acetylcholine receptor that is blocked (rather than activated) by nicotine, binds acetylcholine that is secreted by efferent neurons of the olivocochlear complex that form synapses with the basal plasma membrane of outer hair cells (OHCs) (Elgoyhen et al. 1994, Verbitsky et al. 2000, Elgoyhen et al. 2001, Weisstaub et al. 2002, Gomez-Casati et al. 2005).
Literature References
PubMed ID Title Journal Year
12117536 The alpha9alpha10 nicotinic acetylcholine receptor is permeable to and is modulated by divalent cations

Vetter, DE, Elgoyhen, AB, Weisstaub, N, Katz, E

Hear. Res. 2002
7954834 Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

Elgoyhen, AB, Vetter, DE, Heinemann, S, Johnson, DS, Boulter, J

Cell 1994
15860528 Biophysical and pharmacological characterization of nicotinic cholinergic receptors in rat cochlear inner hair cells

Elgoyhen, AB, Fuchs, PA, Gómez-Casati, ME, Katz, E

J. Physiol. (Lond.) 2005
11044723 Mixed nicotinic-muscarinic properties of the alpha9 nicotinic cholinergic receptor

Elgoyhen, AB, Rothlin, CV, Verbitsky, M, Katz, E

Neuropharmacology 2000
11248107 alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells

Elgoyhen, AB, Heinemann, SF, Vetter, DE, Rothlin, CV, Boulter, J, Katz, E

Proc. Natl. Acad. Sci. U.S.A. 2001
Participants
Input
Output
Orthologous Events
CHRNA9:CHRNA10 binds acetylcholine (Homo sapiens)
Authored
May, B  (2019-11-17)
Reviewed
Dallos, P  (2020-09-14)
Furness, DN  (2020-09-14)
Created
May, B  (2019-11-18)
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