Foxo1,Foxo3 bind Bcl2l11 gene promoter

Stable Identifier
R-RNO-9622586
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Foxo1,Foxo3 bind Bcl2l11 gene promoter

In rat sympathetic neurons, Foxo1 and Foxo3 bind evolutionarily conserved forkhead box elements in the promoter of the Bcl2l11 (Bim gene) upon NGF withdrawal (Gilley et al. 2003) and co-immunoprecipitate with the NF-Y complex which is constitutively associated with the Bcl2l11 gene promoter (Hughes et al. 2011).

Literature References
PubMed ID Title Journal Year
21164521 NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons

Desagher, S, Lassot, I, Mantovani, R, Ham, J, Hughes, R, Kristiansen, M

Cell Death Differ. 2011
12913110 FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

Ham, J, Gilley, J, Coffer, PJ

J. Cell Biol. 2003
Participants
Orthologous Events
Authored
Reviewed
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