Calm1:4xCa2+ binds GluN1:GluN2 (Grin1:Grin2) NMDA receptors and displaces Actn2

Stable Identifier
R-RNO-9617322
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Calm1:4xCa2+ binds GluN1:GluN2 (Grin1:Grin2) NMDA receptors and displaces Actn2

Based on studies in rat neurons, calmodulin (Calm1), activated by binding to calcium ions (Ca2+), after influx of calcium through the pore of activated GluN1:GluN2 (Grin1:Grin2) NMDA receptors, binds to the GluN1 (Grin1, Nr1) subunit of the NMDA receptors (Ehlers et al. 1995). Binding of calcium-calmodulin complex (Calm1:4xCa2+) competes with binding of alpha-actinin-2 (Actn2) to GluN1, leading to dissociation of NMDA receptors from Actn2 (Wyszynski et al. 1997).

Literature References
PubMed ID Title Journal Year
8625412 Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit

Ehlers, MD, Zhang, S, Bernhadt, JP, Huganir, RL

Cell 1996
9009191 Competitive binding of alpha-actinin and calmodulin to the NMDA receptor

Wyszynski, M, Lin, J, Rao, A, Nigh, E, Beggs, AH, Craig, AM, Sheng, M

Nature 1997
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