Formation of di-heterotetramers of GluN1 and GluN2b

Stable Identifier
R-RNO-9609958
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Formation of di-heterotetramers of GluN1 and GluN2b

In rat brain, GluN2B (Grin2b) forms a di-heterotetramer with GluN1 (Grin1). The tetramer includes two molecules of GluN1 and two molecules of GluN2B (Sheng et al. 1994, Karakas and Furukawa 2014). GluN2B expression starts during embryonic development and continues in adult brain (Sheng et al. 1994). Recombinant rat GluN1 and GluN2B form functional NMDA receptors when expressed in Xenopus oocytes (Monyer et al. 1992).

Literature References
PubMed ID Title Journal Year
24876489 Crystal structure of a heterotetrameric NMDA receptor ion channel

Karakas, E, Furukawa, H

Science 2014
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Orthologous Events
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