Reactome | EIF4A3 [cytosol]

EIF4A3 [cytosol]

Stable Identifier

R-RNO-927868

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

Q3B8Q2

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Rattus norvegicus)

- Deadenylation-dependent mRNA decay (Rattus norvegicus)
  - Deadenylation of mRNA (Rattus norvegicus)
    - PAN2-PAN3 complex partially deadenylates mRNA (Rattus norvegicus)
      - Partially Deadenylated mRNA Complex [cytosol] (Rattus norvegicus)
        
        eIF4A [cytosol] (Rattus norvegicus)
        
        EIF4A3 [cytosol] (Rattus norvegicus)
      - Translatable mRNA Complex [cytosol] (Rattus norvegicus)
        
        eIF4A [cytosol] (Rattus norvegicus)
        
        EIF4A3 [cytosol] (Rattus norvegicus)
- Nonsense-Mediated Decay (NMD) (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Rattus norvegicus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        EIF4A3 [cytosol] (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        EIF4A3 [cytosol] (Rattus norvegicus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        EIF4A3 [cytosol] (Rattus norvegicus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        EIF4A3 [cytosol] (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        EIF4A3 [cytosol] (Rattus norvegicus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        EIF4A3 [cytosol] (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        EIF4A3 [cytosol] (Rattus norvegicus)
- Processing of Capped Intron-Containing Pre-mRNA (Rattus norvegicus)
  - Transport of Mature Transcript to Cytoplasm (Rattus norvegicus)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Rattus norvegicus)
      - Transport of the export-competent mRNP complex through the NPC (Rattus norvegicus)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Rattus norvegicus)
        
        EJC [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        EIF4A3 [cytosol] (Rattus norvegicus)
      - mRNP complex dissociates from cytosolic face of NPC (Rattus norvegicus)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Rattus norvegicus)
        
        EJC [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        EIF4A3 [cytosol] (Rattus norvegicus)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Rattus norvegicus)
        
        EJC [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        EIF4A3 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q3B8Q2

Reference Genes

BioGPS Gene:688288

ENSEMBL:ENSRNOG00000045791

ENSEMBL:ENSRNOG00055032767

ENSEMBL:ENSRNOG00060026889

ENSEMBL:ENSRNOG00065004580

KEGG:rno:688288

Monarch:688288

NCBI Gene:688288

UCSC:Q3B8Q2

Reference Transcript

RefSeq:NM_001100158.2

Other Identifiers

1367480_at

17882627

17882628

688288

A_42_P768380

GO:0000184

GO:0000398

GO:0003676

GO:0003723

GO:0003724

GO:0003729

GO:0003824

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0008143

GO:0016071

GO:0017148

GO:0035145

GO:0043226

GO:0045727

GO:0048701

GO:0048856

GO:0071006

GO:0071013

GO:0140098

GO:0140657

GO:2000622

PH_rn_0010920

rc_AI230248_at

Participates

as a member of

eIF4A [cytosol] (Rattus norvegicus)

as a component of

Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)

Other forms of this molecule

EIF4A3 [nucleoplasm]

Inferred From

EIF4A3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001093628.1

ENSEMBL

ENSRNOT00000073140, ENSRNOP00000066302

IntEnz

3.6.4.13

PRO

Q3B8Q2

RGD

1591139

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