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About
What is Reactome ?
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Digital Preservation
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IL5 homodimer [extracellular region]
Stable Identifier
R-RNO-913383
Type
Complex
Species
Rattus norvegicus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-2 family signaling (Rattus norvegicus)
Interleukin receptor SHC signaling (Rattus norvegicus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
14-3-3 zeta binding allows recruitment of PI3K (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Activation of STAT5a/b by JAK2 (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
IL3RB is phosphorylated on Ser-585 (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor SHC signaling (Rattus norvegicus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Interleukin-5 is a homodimer (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
JAK2 is phosphorylated, activated (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
SHP1 and SHP2 bind the common beta chain (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593)-Bc [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
STAT5 is recruited by JAK2 (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
The receptor is activated (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Tyrosine kinases phosphorylate the receptor (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
p-S585-IL3RB binds 14-3-3 proteins (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
p-STAT5 dissociates from the receptor complex (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
RAS GEFs [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Rattus norvegicus)
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
IL5 homodimer [extracellular region] (Rattus norvegicus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
Il5 [extracellular region]
(Rattus norvegicus)
Participates
as an output of
Interleukin-5 is a homodimer (Rattus norvegicus)
as a component of
IL5 homodimer:IL5RA [plasma membrane] (Rattus norvegicus)
Inferred From
IL5 homodimer [extracellular region]
(Homo sapiens)
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