Reactome | Lyn [cytosol]

Lyn [cytosol]

Stable Identifier

R-RNO-912636

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

Tyrosine-protein kinase Lyn, LYN_RAT, Lyn

Locations in the PathwayBrowser

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Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - EPH-Ephrin signaling (Rattus norvegicus)
      - EPH-ephrin mediated repulsion of cells (Rattus norvegicus)
        
        EPHA binds TIAM1 (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        SFKs phosphorylate VAV2,3 (Rattus norvegicus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        p-EPHs bind VAV2,3 (Rattus norvegicus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - EPHA-mediated growth cone collapse (Rattus norvegicus)
        
        NGEF exchanges GTP for GDP on RHOA (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - EPHB-mediated forward signaling (Rattus norvegicus)
        
        EPHB phosphorylates TIAM1 (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        EPHB:NMDAR binds TIAM1 (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Erythropoietin (Rattus norvegicus)
  - EPOR binds EPOR agonists (Rattus norvegicus)
    - EPOR agonists:EPOR:JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
      - EPOR:JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - EPOR:JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
      - Lyn [cytosol] (Rattus norvegicus)
  - Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Rattus norvegicus)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1 (Rattus norvegicus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Rattus norvegicus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Rattus norvegicus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Rattus norvegicus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
      - PI3K bound to EPOR [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Rattus norvegicus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:GAB1 [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
  - Erythropoietin activates RAS (Rattus norvegicus)
    - EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Rattus norvegicus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1 [plasma membrane] (Rattus norvegicus)
        
        EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2 [plasma membrane] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by SCF-KIT (Rattus norvegicus)
    - Dimerization of STATs (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - Disassociation and translocation of STATs to the nucleus (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Rattus norvegicus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - Indirect recruitment of GAB2 to p-KIT (Rattus norvegicus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - JAK2 binds to p-KIT (Rattus norvegicus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - Phosphorylation and activation of VAV1 (Rattus norvegicus)
      - SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - Phosphorylation of GAB2 by SFKs (Rattus norvegicus)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - Phosphorylation of JAK2 (Rattus norvegicus)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - Phosphorylation of SHP2 by SFKs (Rattus norvegicus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - Phosphorylation of STATs (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Rattus norvegicus)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - Recruitment of STATs (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - Regulation of KIT signaling (Rattus norvegicus)
      - Interaction of APS and p-KIT (Rattus norvegicus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - Phosphorylation of APS (Rattus norvegicus)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - Recruitment of CBL to KIT (Rattus norvegicus)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - SHP2 interacts with p-KIT (Rattus norvegicus)
      - SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)
    - Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        SFKs:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Rattus norvegicus)
        
        Lyn [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q07014 Lyn

Gene Names

Lyn

Chain

initiator methionine:, chain:2-512

Reference Genes

BioGPS Gene:81515 Lyn

KEGG:rno:81515 Lyn

Monarch:81515 Lyn

NCBI Gene:81515 Lyn

UCSC:Q07014 Lyn

Reference Transcript

Other Identifiers

10867461

1368679_a_at

1382346_at

1387277_at

17797097

5639378

5671198

5754967

5768717

5801431

5844063

5961595

6103285

6132399

6165179

6168291

6168366

6188997

6439622

6474028

6481820

6526236

6564238

6665033

6693681

81515

A_44_P273821

A_44_P316239

A_64_P048980

GE16636

GO:0000077

GO:0001782

GO:0001817

GO:0001933

GO:0001934

GO:0002244

GO:0002376

GO:0002431

GO:0002513

GO:0002576

GO:0002762

GO:0002768

GO:0002774

GO:0002902

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005794

GO:0005886

GO:0006468

GO:0006954

GO:0006974

GO:0007155

GO:0007169

GO:0008284

GO:0008285

GO:0009725

GO:0009898

GO:0009986

GO:0010976

GO:0012501

GO:0016192

GO:0016740

GO:0017124

GO:0023052

GO:0030097

GO:0030154

GO:0030218

GO:0030222

GO:0030335

GO:0030889

GO:0031175

GO:0031663

GO:0032991

GO:0033003

GO:0033628

GO:0034136

GO:0034142

GO:0034144

GO:0035556

GO:0036211

GO:0038043

GO:0038159

GO:0042060

GO:0042531

GO:0043226

GO:0043231

GO:0043304

GO:0043410

GO:0044325

GO:0044877

GO:0045121

GO:0045646

GO:0046875

GO:0048471

GO:0048856

GO:0048870

GO:0050727

GO:0050853

GO:0050855

GO:0051279

GO:0055065

GO:0055085

GO:0070372

GO:0070373

GO:0070667

GO:0070668

GO:0071300

GO:0090025

GO:0090330

GO:0097028

GO:0097110

GO:0098542

GO:0140031

GO:0140096

GO:0141038

GO:1902532

GO:2000670

ILMN_1372831

L14782_s_at

L14951_at

PH_rn_0003029

rc_AA946044_s_at

rc_AI012049_at

Participates

as a component of

as a candidate of

as a member of

as an input of

GPVI binds Fyn and Lyn (Rattus norvegicus)

Other forms of this molecule

MyrG2-PalmC3-LYN [lysosomal membrane]

MyrG2-PalmC3-LYN [endocytic vesicle membrane]

LYN [plasma membrane]

phospho-p-Y397-LYN [cytosol]

phospho-p-Y397-LYN [plasma membrane]

MyrG2-PalmC3-LYN [plasma membrane]

Inferred From

LYN [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001104568.1, XP_006237896.1, NP_110484.1

ZINC - Metabolites

LYN_RAT

ZINC - World Drugs

LYN_RAT

ENSEMBL

ENSRNOT00000011130, ENSRNOG00000008180, ENSRNOP00000011130

ZINC - Substances

LYN_RAT

ZINC - Biogenic

LYN_RAT

ZINC target

Q07014

PRO

Q07014

RGD

621017

ZINC - Predictions - Purchasable

LYN_RAT

HMDB Protein

HMDBP13825

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