Reactome | Atp6v1g2 [cytosol]

Atp6v1g2 [cytosol]

Stable Identifier

R-RNO-912588

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

ATP6V1G2, Q8R2H0

Locations in the PathwayBrowser

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Cellular responses to stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Cellular response to starvation (Rattus norvegicus)
    - Amino acids regulate mTORC1 (Rattus norvegicus)
      - RRAGA,B exchanges GDP for GTP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
      - RRAGA,B hydrolyzes GTP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
      - RRAGC,D exchanges GTP for GDP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
      - RRAGC,D hydrolyzes GTP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
      - mTORC1 binds RHEB:GTP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)

Immune System (Rattus norvegicus)

- Innate Immune System (Rattus norvegicus)
  - ROS and RNS production in phagocytes (Rattus norvegicus)
    - Intraphagosomal pH is lowered to 5 by V-ATPase (Rattus norvegicus)
      - V-ATPase [phagocytic vesicle membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by Insulin receptor (Rattus norvegicus)
    - Insulin receptor recycling (Rattus norvegicus)
      - ATP6AP1 binds V-ATPase (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
      - Endosome acidification (Rattus norvegicus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)

Transport of small molecules (Rattus norvegicus)

- Ion channel transport (Rattus norvegicus)
  - ATP6AP1 binds V-ATPase (Rattus norvegicus)
    - V-ATPase [endosome membrane] (Rattus norvegicus)
      - ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
    - V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
      - V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
- Iron uptake and transport (Rattus norvegicus)
  - Transferrin endocytosis and recycling (Rattus norvegicus)
    - ATP6AP1 binds V-ATPase (Rattus norvegicus)
      - V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)
    - Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1G dimer [cytosol] (Rattus norvegicus)
        
        ATP6V1G [cytosol] (Rattus norvegicus)
        
        Atp6v1g2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q8R2H0

Gene Names

Atp6v1g2

Reference Genes

BioGPS Gene:368044 Atp6v1g2

ENSEMBL:ENSRNOG00000000840

ENSEMBL:ENSRNOG00000000840.7 Atp6v1g2

KEGG Gene (Rattus norvegicus):368044 Atp6v1g2

Monarch:368044 Atp6v1g2

NCBI Gene:368044 Atp6v1g2

UCSC:Q8R2H0 Atp6v1g2

Reference Transcript

RefSeq:NM_212490.2 Atp6v1g2

Other Identifiers

10831152

1377722_at

17756339

368044

5739661

5856270

5989390

6269779

6468945

6502847

6685795

A_44_P484719

A_44_P555236

A_64_P128256

GE1237920

GE16183

GO:0003824

GO:0005215

GO:0005773

GO:0016192

GO:0016471

GO:0016787

GO:0016887

GO:0030672

GO:0031410

GO:0043226

GO:0046961

GO:0055085

GO:0097401

GO:0140657

GO:1902600

ILMN_1366718

PH_rn_0005628

PH_rn_0020951

Participates

as a member of

ATP6V1G [cytosol] (Rattus norvegicus)

Inferred From

ATP6V1G2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_997655.1

Ensembl

ENSRNOT00000001114, ENSRNOG00000000840, ENSRNOP00000001114

RGD

1303186

PDB

6VQB, 6VQA, 6VQJ, 6VQ8, 6VQ6, 6VQI, 6VQ9, 6VQ7, 6VQK

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