Reactome | Atp6v1c1 [cytosol]

Atp6v1c1 [cytosol]

Stable Identifier

R-RNO-912586

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

ATP6V1C1, Q5FVI6

Locations in the PathwayBrowser

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Cellular responses to stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Cellular response to starvation (Rattus norvegicus)
    - Amino acids regulate mTORC1 (Rattus norvegicus)
      - RRAGA,B exchanges GDP for GTP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
      - RRAGA,B hydrolyzes GTP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
      - RRAGC,D exchanges GTP for GDP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
      - RRAGC,D hydrolyzes GTP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
      - mTORC1 binds RHEB:GTP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by Insulin receptor (Rattus norvegicus)
    - Insulin receptor recycling (Rattus norvegicus)
      - ATP6AP1 binds V-ATPase (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
      - Endosome acidification (Rattus norvegicus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)

Transport of small molecules (Rattus norvegicus)

- Ion channel transport (Rattus norvegicus)
  - ATP6AP1 binds V-ATPase (Rattus norvegicus)
    - V-ATPase [endosome membrane] (Rattus norvegicus)
      - ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
    - V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
      - V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
- Iron uptake and transport (Rattus norvegicus)
  - Transferrin endocytosis and recycling (Rattus norvegicus)
    - ATP6AP1 binds V-ATPase (Rattus norvegicus)
      - V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)
    - Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q5FVI6

Gene Names

Atp6v1c1

Reference Genes

BioGPS Gene:299971 Atp6v1c1

ENSEMBL:ENSRNOG00000004846

ENSEMBL:ENSRNOG00000004846.6 Atp6v1c1

ENSEMBL:ENSRNOG00055023757

ENSEMBL:ENSRNOG00060007035

ENSEMBL:ENSRNOG00065003837

KEGG Gene (Rattus norvegicus):299971 Atp6v1c1

Monarch:299971 Atp6v1c1

NCBI Gene:299971 Atp6v1c1

UCSC:Q5FVI6 Atp6v1c1

Reference Transcript

RefSeq:NM_001011992.1 Atp6v1c1

Other Identifiers

10896234

1374396_at

17829048

299971

5650451

5658480

5828803

6064687

6077160

6134310

6302214

6439467

6458782

6491241

6517228

6521991

6533305

6544144

6609800

6643920

A_43_P16458

A_44_P1029543

A_64_P022263

GE14238

GO:0005215

GO:0005886

GO:0015078

GO:0016192

GO:0033176

GO:0033180

GO:0046961

GO:0055085

GO:0097401

GO:0140657

GO:1902495

GO:1902600

GO:1904949

ILMN_1375808

ILMN_1376957

PH_rn_0003858

rc_AA799824_at

rc_AA819556_at

Participates

as a member of

ATP6V1C [cytosol] (Rattus norvegicus)

Inferred From

ATP6V1C1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001011992.1

Ensembl

ENSRNOG00000004846, ENSRNOT00000006917, ENSRNOP00000006917

PRO

Q5FVI6

RGD

1311082

PDB

6VQ7, 6VQ8, 6VQ6, 6VQI, 6VQK, 6VQJ

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