Reactome | Atp6v1c2 [cytosol]

Atp6v1c2 [cytosol]

Stable Identifier

R-RNO-912573

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

ATP6V1C2, Q6AYE4

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Cellular response to starvation (Rattus norvegicus)
    - Amino acids regulate mTORC1 (Rattus norvegicus)
      - RRAGA,B exchanges GDP for GTP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
      - RRAGA,B hydrolyzes GTP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
      - RRAGC,D exchanges GTP for GDP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
      - RRAGC,D hydrolyzes GTP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
      - mTORC1 binds RHEB:GTP (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Rattus norvegicus)
        
        v-ATPase [lysosomal membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by Insulin receptor (Rattus norvegicus)
    - Insulin receptor recycling (Rattus norvegicus)
      - ATP6AP1 binds V-ATPase (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
      - Endosome acidification (Rattus norvegicus)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)

Transport of small molecules (Rattus norvegicus)

- Ion channel transport (Rattus norvegicus)
  - ATP6AP1 binds V-ATPase (Rattus norvegicus)
    - V-ATPase [endosome membrane] (Rattus norvegicus)
      - ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
    - V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
      - V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
- Iron uptake and transport (Rattus norvegicus)
  - Transferrin endocytosis and recycling (Rattus norvegicus)
    - ATP6AP1 binds V-ATPase (Rattus norvegicus)
      - V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)
    - Acidification of Tf:TfR1 containing endosome (Rattus norvegicus)
      - V-ATPase:ATP6AP1 [endosome membrane] (Rattus norvegicus)
        
        V-ATPase [endosome membrane] (Rattus norvegicus)
        
        ATP6V1 [cytosol] (Rattus norvegicus)
        
        ATP6V1C [cytosol] (Rattus norvegicus)
        
        Atp6v1c2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q6AYE4

Gene Names

Atp6v1c2

Reference Genes

BioGPS Gene:362802 Atp6v1c2

ENSEMBL:ENSRNOG00000050553

ENSEMBL:ENSRNOG00000050553.3 Atp6v1c2

ENSEMBL:ENSRNOG00055005725

ENSEMBL:ENSRNOG00060003957

ENSEMBL:ENSRNOG00065005630

KEGG Gene (Rattus norvegicus):362802 Atp6v1c2

Monarch:362802 Atp6v1c2

NCBI Gene:362802 Atp6v1c2

Reference Transcript

RefSeq:NM_001014199.1 Atp6v1c2

Other Identifiers

10940631

1376239_at

17881819

362802

5671230

5747361

5847130

5883460

5920734

6151608

6296296

6392542

6415847

6481829

6618167

6650957

A_44_P382482

GE18153

GO:0005215

GO:0006811

GO:0015078

GO:0033180

GO:0046961

GO:0055085

GO:0140657

GO:1902600

ILMN_1371030

PH_rn_0005894

rc_AA817977_s_at

Participates

as a member of

ATP6V1C [cytosol] (Rattus norvegicus)

Inferred From

ATP6V1C2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001014221.1

Ensembl

ENSRNOP00000093823, ENSRNOT00000099858, ENSRNOT00000071977, ENSRNOP00000066981, ENSRNOG00000050553

PRO

Q6AYE4

RGD

1359430

Cite Us!