(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine

Stable Identifier
R-RNO-909775
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
mitochondrial matrix
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine
Mitochondrial Agxt2 tetramer catalyzes the reaction of (R)-3-aminoisobutyric acid and pyruvate to form 2-methyl-3-oxopropanoate and alanine (Lee et al. 1995; Tamaki et al. 1990).
Literature References
PubMed ID Title Journal Year
2158891 Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver

Tamaki, N, Kaneko, M, Mizota, C, Kikugawa, M, Fujimoto, S

Eur J Biochem 1990
7592550 Molecular cloning and sequencing of a cDNA encoding alanine-glyoxylate aminotransferase 2 from rat kidney

Lee, IS, Muragaki, Y, Ideguchi, T, Hase, T, Tsuji, M, Ooshima, A, Okuno, E, Kido, R

J Biochem 1995
Participants
Input
Output
Catalyst Activity

(R)-3-amino-2-methylpropionate-pyruvate transaminase activity of Agxt2 tetramer [mitochondrial matrix]

Physical Entity
Agxt2 tetramer [mitochondrial matrix] (Rattus norvegicus)
Activity
(R)-3-amino-2-methylpropionate-pyruvate transaminase activity (GO:0047305)
Orthologous Events
(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine (Homo sapiens)
Authored
D'Eustachio, P  (2010-07-08)
Reviewed
Jassal, B  (2010-11-09)
Created
D'Eustachio, P  (2010-07-08)
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