miR-132 Endonucleolytic Minimal RISC [cytosol]

Stable Identifier
R-RNO-9021278
Type
Complex
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Argonaute2: miR-132 (single-stranded)
General
The RNA-induced silencing complex contains an Argonaute (AGO) protein, whose PAZ domain binds the 3' end of the miRNA. The PIWI domain of AGO is responsible for cleavage of target RNAs, that is, RNAs complementary to the miRNA. Only AGO2 (EIF2C2) is capable of cleavage, however. AGO1 (EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) repress translation of target RNAs by binding without cleavage.
Participants
components
Participates
as a component of
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