Grin2b gene expression is inhibited by Mecp2

Stable Identifier
R-RNO-9020540
Type
Reaction [omitted]
Species
Rattus norvegicus
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Grin2b gene expression is inhibited by Mecp2

Transcription of the rat Grin2b (Nr2b) gene, encoding glutamate (NMDA) receptor subunit epsilon-2, is inhibited by promoter methylation and subsequent Mecp2 binding. Grin2b promoter methylation and Mecp2 binding are stimulated by neuronal activity. Suppression of neuronal activity leads to demethylation of the Grin2b promoter and increased Grin2b transcription (Lee et al. 2008).

Literature References
PubMed ID Title Journal Year
18952054 Activity-dependent NR2B expression is mediated by MeCP2-dependent epigenetic regulation

Lee, S, Kim, W, Ham, BJ, Chen, W, Bear, MF, Yoon, BJ

Biochem. Biophys. Res. Commun. 2008
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