Reactome | Commd7 [cytosol]

Commd7 [cytosol]

Stable Identifier

R-RNO-8955104

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

COMMD7, F7FBG3

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - 26S proteasome degrades HIFalpha (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd7 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:F7FBG3

Gene Names

Commd7

Reference Genes

ENSEMBL:ENSRNOG00000010538

ENSEMBL:ENSRNOG00000010538.8 Commd7

Other Identifiers

10850878

1376493_at

1377126_at

17778405

296285

5758350

5805997

5824739

6263295

6488045

6655288

6656034

6731998

6738278

A_43_P17772

GE12509

GO:0006351

GO:0006355

GO:0023052

GO:0033209

GO:0045892

GO:0051059

ILMN_1350253

PH_rn_0006333

rc_AA850785_at

Participates

as a candidate of

COMMDs [cytosol] (Rattus norvegicus)

Other forms of this molecule

Commd7 [nucleoplasm]

Inferred From

COMMD7 [cytosol] (Homo sapiens)

Cross References

Ensembl

ENSRNOT00000014038, ENSRNOG00000010538, ENSRNOP00000014038

RGD

1307786

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